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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F07%3A00006173%21RIV08-MSM-25310___
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Background. The disbalance of redox equilibrium and chronic inflammatory status play a role in pathophysiology of atherosclerosis. The aim was to asses the impact of systemic inflammation, oxidative stress and antioxidative status in patients with advanced coronary artery disease. Methods. Inflammatory and oxidative stress parameters were determined in group of patients with serious coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of other coronary artery according to coronarographic examination; S, n=40) and control group of healthy people (C, n=48). Total amount of free radicals was determined by spectrophotometric assay; malondialdehyde, glutathione, homocysteine and alpha-tocopherol plasma concentrations by HPLC. Plasma levels of hsCRP, alpha1antiproteinase, total cholesterol, triglycerides, HDL-ch, LDL-ch, albumin, fibrinogen were monitored. Results. In patients with coronary stenosis (S) higher level of free radicals (FR) coincided with higher Background. The disbalance of redox equilibrium and chronic inflammatory status play a role in pathophysiology of atherosclerosis. The aim was to asses the impact of systemic inflammation, oxidative stress and antioxidative status in patients with advanced coronary artery disease. Methods. Inflammatory and oxidative stress parameters were determined in group of patients with serious coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of other coronary artery according to coronarographic examination; S, n=40) and control group of healthy people (C, n=48). Total amount of free radicals was determined by spectrophotometric assay; malondialdehyde, glutathione, homocysteine and alpha-tocopherol plasma concentrations by HPLC. Plasma levels of hsCRP, alpha1antiproteinase, total cholesterol, triglycerides, HDL-ch, LDL-ch, albumin, fibrinogen were monitored. Results. In patients with coronary stenosis (S) higher level of free radicals (FR) coincided with higher Oxidační stres a zánětlivé markery u pokročilého onemocnění koronárních tepen
dcterms:title
Oxidative stress and inflammatory markers in advanced coronary artery disease Oxidative stress and inflammatory markers in advanced coronary artery disease Oxidační stres a zánětlivé markery u pokročilého onemocnění koronárních tepen
skos:prefLabel
Oxidative stress and inflammatory markers in advanced coronary artery disease Oxidační stres a zánětlivé markery u pokročilého onemocnění koronárních tepen Oxidative stress and inflammatory markers in advanced coronary artery disease
skos:notation
RIV/00216275:25310/07:00006173!RIV08-MSM-25310___
n3:strany
S43-S44
n3:aktivita
n12:Z n12:P
n3:aktivity
P(OC 124), Z(MSM0021627502)
n3:dodaniDat
n15:2008
n3:domaciTvurceVysledku
n13:1113259 n13:2726955 n13:2054744 n13:6862519 n13:2131188
n3:druhVysledku
n19:D
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
440391
n3:idVysledku
RIV/00216275:25310/07:00006173
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Oxidative stress; inflammation; coronary artery disease
n3:klicoveSlovo
n8:coronary%20artery%20disease n8:Oxidative%20stress n8:inflammation
n3:kontrolniKodProRIV
[9DCB15C0621C]
n3:mistoVydani
London
n3:nazevZdroje
Free Radical Research
n3:obor
n16:ED
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:projekt
n14:OC%20124
n3:rokUplatneniVysledku
n15:2007
n3:tvurceVysledku
Žáková, Pavla Kanďár, Roman Skalický, Jiří Vojtíšek, Petr Meloun, Milan Roušar, Tomáš Kovařík, Jakub Mužáková, Vladimíra
n3:zamer
n20:MSM0021627502
s:issn
1071-5762
s:numberOfPages
2
n11:hasPublisher
Informa Healthcare UK
n17:organizacniJednotka
25310