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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F04%3A00001657%21RIV08-MSM-25310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer´s disease treatment ? rivastigmine and galanthamine. Schopnost nových karbamátů a karbazátů inhibovat hydrolýzu acetylcholinu byla testována stanovením indexu pI50, což je záporný dekadický logaritmus molární koncentrace ihibitoru snižující aktivitu (rychlost inhibice) o 50%. Získané výsledy byly porovnány s hodnotami platnými pro oficiální léčiva Alzheimerovy choroby ? Rivastigmin a Galantamin. The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer´s disease treatment ? rivastigmine and galanthamine.
dcterms:title
Half-inhibition concentrations of new cholinesterase inhibitors. Half-inhibition concentrations of new cholinesterase inhibitors. Index pI50 nových inhibitorů cholinesteráz.
skos:prefLabel
Half-inhibition concentrations of new cholinesterase inhibitors. Half-inhibition concentrations of new cholinesterase inhibitors. Index pI50 nových inhibitorů cholinesteráz.
skos:notation
RIV/00216275:25310/04:00001657!RIV08-MSM-25310___
n4:strany
293-296
n4:aktivita
n12:Z
n4:aktivity
Z(MSM 253100001)
n4:cisloPeriodika
c
n4:dodaniDat
n11:2008
n4:domaciTvurceVysledku
n13:2747472 n13:8088462
n4:druhVysledku
n5:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
565898
n4:idVysledku
RIV/00216275:25310/04:00001657
n4:jazykVysledku
n6:eng
n4:klicovaSlova
cholinesterases; inhibitors; index pI(50)
n4:klicoveSlovo
n10:index%20pI%2850%29 n10:inhibitors n10:cholinesterases
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[CF1C15F03FD2]
n4:nazevZdroje
Z. Naturforsch.
n4:obor
n17:CE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n11:2004
n4:svazekPeriodika
59
n4:tvurceVysledku
Čegan, Alexander Ventura, Karel Zdražilová, Pavla Komers, Karel Štěpánková, Šárka
n4:zamer
n14:MSM%20253100001
s:issn
0939-5075
s:numberOfPages
14
n3:organizacniJednotka
25310