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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F03%3A00000548%21RIV08-MSM-25310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů The set of four water-soluble (3-methoxypropyl)stannanes with the general formula (CH3OCH2CH2CH2)xSnCl4-x where x = 4 (1), x = 3 (2), x = 2 (3) and x = 1 (4), was prepared. For 3 and 4, which were isolated in crystalline state, it was shown by X ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometry, respectively, i.e. in both cases, the oxygen atoms of 3-methoxypropyl groups were coordinated to the central tin atom forming chelates. For all compounds, structures in CDCl3 and DMSO-d6 solutions were proposed from 13C and 119Sn NMR spectra. In CDCl3 solutions, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of 3 methoxypropyl substituent was evaluated on the basis of 17O NMR chemical shifts and 3,6J(1H,119Sn) long-range coupling constants. Compounds 2 and 3 exhibited promising in vitro antitumour and trypanocidal activity. The set of four water-soluble (3-methoxypropyl)stannanes with the general formula (CH3OCH2CH2CH2)xSnCl4-x where x = 4 (1), x = 3 (2), x = 2 (3) and x = 1 (4), was prepared. For 3 and 4, which were isolated in crystalline state, it was shown by X ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometry, respectively, i.e. in both cases, the oxygen atoms of 3-methoxypropyl groups were coordinated to the central tin atom forming chelates. For all compounds, structures in CDCl3 and DMSO-d6 solutions were proposed from 13C and 119Sn NMR spectra. In CDCl3 solutions, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of 3 methoxypropyl substituent was evaluated on the basis of 17O NMR chemical shifts and 3,6J(1H,119Sn) long-range coupling constants. Compounds 2 and 3 exhibited promising in vitro antitumour and trypanocidal activity.
dcterms:title
Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides
skos:prefLabel
Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides
skos:notation
RIV/00216275:25310/03:00000548!RIV08-MSM-25310___
n4:strany
143-148
n4:aktivita
n16:P
n4:aktivity
P(LN00A028)
n4:cisloPeriodika
N
n4:dodaniDat
n6:2008
n4:domaciTvurceVysledku
n8:8074453
n4:druhVysledku
n15:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
630089
n4:idVysledku
RIV/00216275:25310/03:00000548
n4:jazykVysledku
n13:eng
n4:klicovaSlova
Tin; Chelates; O ligands; Structure elucidation; Drug research
n4:klicoveSlovo
n11:Tin n11:Drug%20research n11:Chelates n11:Structure%20elucidation n11:O%20ligands
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[AC5488315623]
n4:nazevZdroje
European Journal of Inorganic Chemistry
n4:obor
n18:CA
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:projekt
n9:LN00A028
n4:rokUplatneniVysledku
n6:2003
n4:svazekPeriodika
1
n4:tvurceVysledku
Lébl, Tomáš Smička, Aleš Brus, Jiří Bruhn, Clemens
s:issn
1434-1948
s:numberOfPages
6
n17:organizacniJednotka
25310