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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00079244%21RIV15-MSM-14740___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
The decrease of TCR diversity with aging has never been studied by direct methods. In this study, we combined high-throughput Illumina sequencing with unique cDNA molecular identifier technology to achieve deep and precisely normalized profiling of TCR beta repertoires in 39 healthy donors aged 6-90 y. We demonstrate that TCR beta diversity per 10(6) T cells decreases roughly linearly with age, with significant reduction already apparent by age 40. The percentage of naive T cells showed a strong correlation with measured TCR diversity and decreased linearly up to age 70. Remarkably, the oldest group (average age 82 y) was characterized by a higher percentage of naive CD4(+) T cells, lower abundance of expanded clones, and increased TCR diversity compared with the previous age group (average age 62 y), suggesting the influence of age selection and association of these three related parameters with longevity. The decrease of TCR diversity with aging has never been studied by direct methods. In this study, we combined high-throughput Illumina sequencing with unique cDNA molecular identifier technology to achieve deep and precisely normalized profiling of TCR beta repertoires in 39 healthy donors aged 6-90 y. We demonstrate that TCR beta diversity per 10(6) T cells decreases roughly linearly with age, with significant reduction already apparent by age 40. The percentage of naive T cells showed a strong correlation with measured TCR diversity and decreased linearly up to age 70. Remarkably, the oldest group (average age 82 y) was characterized by a higher percentage of naive CD4(+) T cells, lower abundance of expanded clones, and increased TCR diversity compared with the previous age group (average age 62 y), suggesting the influence of age selection and association of these three related parameters with longevity.
dcterms:title
Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling
skos:prefLabel
Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling
skos:notation
RIV/00216224:14740/14:00079244!RIV15-MSM-14740___
n3:aktivita
n9:P
n3:aktivity
P(ED1.1.00/02.0068)
n3:cisloPeriodika
6
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
Chudakov, Dmitriy
n3:druhVysledku
n10:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
1851
n3:idVysledku
RIV/00216224:14740/14:00079244
n3:jazykVysledku
n13:eng
n3:klicovaSlova
T-CELL REPERTOIRE; RECEPTOR DIVERSITY; THYMIC INVOLUTION; IMMUNE DEFENSE; OLD PRIMATES; IFN-GAMMA; TNF-ALPHA; RESPONSES; HOMEOSTASIS; GENERATION
n3:klicoveSlovo
n5:IMMUNE%20DEFENSE n5:TNF-ALPHA n5:RECEPTOR%20DIVERSITY n5:IFN-GAMMA n5:GENERATION n5:RESPONSES n5:OLD%20PRIMATES n5:HOMEOSTASIS n5:T-CELL%20REPERTOIRE n5:THYMIC%20INVOLUTION
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[F90E7AC9094D]
n3:nazevZdroje
Journal of immunology
n3:obor
n16:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:projekt
n8:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
192
n3:tvurceVysledku
Lebedev, Y.B. Lukyanov, S. Bolotin, D. A. Shugay, M. Bogdanova, E. A. Chudakov, Dmitriy Britanova, O. V. Staroverov, D. B. Merzlyak, E. M. Mamedov, I.Z. Putintseva, E. V. Turchaninova, M. A.
n3:wos
000332702700018
s:issn
0022-1767
s:numberOfPages
10
n7:doi
10.4049/jimmunol.1302064
n17:organizacniJednotka
14740