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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00078951%21RIV15-MSM-14740___
rdf:type
n17:Vysledek skos:Concept
rdfs:seeAlso
http://www.hindawi.com/journals/bmri/2014/691041/
dcterms:description
Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines. The goal of the present study was to investigate expression of proinflammatory (IL-1b, TNFa) and anti-inflammatory cytokines (IL-4, IL-10) in activated Schwann cells in relation to growing axons distal to crush injury of rat sciatic nerves. Seven days fromsciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43). The Schwann cells of naive sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines. In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion. The cytokinepositive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43. Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines. The goal of the present study was to investigate expression of proinflammatory (IL-1b, TNFa) and anti-inflammatory cytokines (IL-4, IL-10) in activated Schwann cells in relation to growing axons distal to crush injury of rat sciatic nerves. Seven days fromsciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43). The Schwann cells of naive sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines. In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion. The cytokinepositive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43.
dcterms:title
Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury
skos:prefLabel
Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury
skos:notation
RIV/00216224:14740/14:00078951!RIV15-MSM-14740___
n3:aktivita
n13:P
n3:aktivity
P(ED1.1.00/02.0068)
n3:cisloPeriodika
April
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n12:6754937 n12:5568692 n12:7731361
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
21290
n3:idVysledku
RIV/00216224:14740/14:00078951
n3:jazykVysledku
n14:eng
n3:klicovaSlova
activated Schwann cell; growing axons; reinnervation; inflammatory mediators
n3:klicoveSlovo
n7:growing%20axons n7:inflammatory%20mediators n7:reinnervation n7:activated%20Schwann%20cell
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[B8E4AFF4A8AD]
n3:nazevZdroje
BioMed Research International
n3:obor
n4:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n15:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
2014
n3:tvurceVysledku
Dubový, Petr Hradilová Svíženská, Ivana Klusáková, Ilona
n3:wos
000335836400001
s:issn
2314-6133
s:numberOfPages
7
n19:doi
10.1155/2014/691041
n20:organizacniJednotka
14740