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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00078422%21RIV15-MSM-14740___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://www.bloodjournal.org/content/124/1/84
dcterms:description
We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia cell expression levels that varied among patients. CLL cells that expressed zeta-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had a median expression level of miR-150 that was significantly lower than that of ZAP-70-negative CLL cells or those that used mutated IGHV genes. In samples stratified for expression of miR-150, CLL cells with low-level miR-150 expressed relatively higher levels of forkhead box P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3' untranslated regions having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that enhance B-cell receptor signaling, a putative CLL-growth/survival signal. We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia cell expression levels that varied among patients. CLL cells that expressed zeta-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had a median expression level of miR-150 that was significantly lower than that of ZAP-70-negative CLL cells or those that used mutated IGHV genes. In samples stratified for expression of miR-150, CLL cells with low-level miR-150 expressed relatively higher levels of forkhead box P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3' untranslated regions having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that enhance B-cell receptor signaling, a putative CLL-growth/survival signal.
dcterms:title
miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1 miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1
skos:prefLabel
miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1 miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1
skos:notation
RIV/00216224:14740/14:00078422!RIV15-MSM-14740___
n4:aktivita
n5:P
n4:aktivity
P(EE2.3.30.0009)
n4:cisloPeriodika
1
n4:dodaniDat
n15:2015
n4:domaciTvurceVysledku
n7:4382749
n4:druhVysledku
n9:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
29512
n4:idVysledku
RIV/00216224:14740/14:00078422
n4:jazykVysledku
n8:eng
n4:klicovaSlova
GENE MUTATION STATUS; DOWN-REGULATION; C-MYB; DISEASE PROGRESSION; PROTEIN EXPRESSION; CD38 EXPRESSION; CLL PATIENTS; MICRORNAS; ZAP-70; APOPTOSIS
n4:klicoveSlovo
n11:MICRORNAS n11:APOPTOSIS n11:DOWN-REGULATION n11:PROTEIN%20EXPRESSION n11:CLL%20PATIENTS n11:DISEASE%20PROGRESSION n11:CD38%20EXPRESSION n11:ZAP-70 n11:C-MYB n11:GENE%20MUTATION%20STATUS
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[3C61891F88A3]
n4:nazevZdroje
Blood
n4:obor
n20:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
10
n4:projekt
n10:EE2.3.30.0009
n4:rokUplatneniVysledku
n15:2014
n4:svazekPeriodika
124
n4:tvurceVysledku
Ghia, E. M. Li, H. Y. Mráz, Marek Chen, L. G. Rassenti, L.Z. Smith, E. N. Messer, K. Kipps, T. J. Jepsen, K. Frazer, K. A.
n4:wos
000342618300015
s:issn
0006-4971
s:numberOfPages
12
n16:doi
10.1182/blood-2013-09-527234
n14:organizacniJednotka
14740