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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00078064%21RIV15-MSM-14740___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S104366181400067X
dcterms:description
In recent years, several studies have explored the involvement of the deregulation of the hypothalamus-pituitary-adrenal (HPA) axis in the pathophysiology of stress-related disorders. HPA hyper-activation as a consequence of acute/chronic stress has been found to play a major role in the neurobiological changes that are responsible for the onset of such states. Currently available medications for depression, one of the most relevant stress-related disorders, present several limitations, including a time lag for treatment response and low rates of efficacy. N-Arachidonoylserotonin (AA-5-HT), a dual blocker at fatty acid amide hydrolase (FAAH, the enzyme responsible for the inactivation of the endocannabinoid anandamide) and transient receptor potential vanilloid type-1 channel (TRPV1), produces anxiolytic-like effects in mice. The present study was designed to assess the capability of AA-5-HT to reverse the behavioral despair following exposure to stress in rats and the role of the HPA-axis. In recent years, several studies have explored the involvement of the deregulation of the hypothalamus-pituitary-adrenal (HPA) axis in the pathophysiology of stress-related disorders. HPA hyper-activation as a consequence of acute/chronic stress has been found to play a major role in the neurobiological changes that are responsible for the onset of such states. Currently available medications for depression, one of the most relevant stress-related disorders, present several limitations, including a time lag for treatment response and low rates of efficacy. N-Arachidonoylserotonin (AA-5-HT), a dual blocker at fatty acid amide hydrolase (FAAH, the enzyme responsible for the inactivation of the endocannabinoid anandamide) and transient receptor potential vanilloid type-1 channel (TRPV1), produces anxiolytic-like effects in mice. The present study was designed to assess the capability of AA-5-HT to reverse the behavioral despair following exposure to stress in rats and the role of the HPA-axis.
dcterms:title
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis
skos:prefLabel
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis
skos:notation
RIV/00216224:14740/14:00078064!RIV15-MSM-14740___
n3:aktivita
n15:P
n3:aktivity
P(ED1.1.00/02.0068)
n3:cisloPeriodika
September
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
Micale, Vincenzo
n3:druhVysledku
n4:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
12463
n3:idVysledku
RIV/00216224:14740/14:00078064
n3:jazykVysledku
n19:eng
n3:klicovaSlova
N-Arachidonoylserotonin; HPA-axis; Stress; FAAH; TRPV1
n3:klicoveSlovo
n6:TRPV1 n6:Stress n6:HPA-axis n6:FAAH n6:N-Arachidonoylserotonin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[105D5E1BC5C7]
n3:nazevZdroje
PHARMACOLOGICAL RESEARCH
n3:obor
n7:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:projekt
n9:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
87
n3:tvurceVysledku
Iannotti, F. A. Camillieri, G. Verde, R. Tamburella, A. Di, Marzo V. Gozzo, L. Navarria, A. Leggio, G. M. Imperatore, R. Drago, F. Micale, Vincenzo
n3:wos
000341474400016
s:issn
1043-6618
s:numberOfPages
9
n10:doi
10.1016/j.phrs.2014.04.014
n18:organizacniJednotka
14740