This HTML5 document contains 61 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n7http://localhost/temp/predkladatel/
n6http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n4http://linked.opendata.cz/resource/domain/vavai/projekt/
n9http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
rdfshttp://www.w3.org/2000/01/rdf-schema#
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n11http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14740%2F14%3A00077731%21RIV15-MSM-14740___/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n20http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n5http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00077731%21RIV15-MSM-14740___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912964/pdf/0990329.pdf
dcterms:description
In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can be problematic, especially if the different rearrangements have discordant mutational status. To gain insight into the possible biological mechanisms underlying the origin of the multiple rearrangements, we performed a comprehensive immunogenetic and immunophenotypic characterization of 31 cases with the multiple rearrangements identified in a cohort of 1147 patients with chronic lymphocytic leukemia. For the majority of cases (25/31), we provide evidence of the co-existence of at least two B lymphocyte clones with a chronic lymphocytic leukemia phenotype. We also identified clonal drifts in serial samples, likely driven by selection forces. In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can be problematic, especially if the different rearrangements have discordant mutational status. To gain insight into the possible biological mechanisms underlying the origin of the multiple rearrangements, we performed a comprehensive immunogenetic and immunophenotypic characterization of 31 cases with the multiple rearrangements identified in a cohort of 1147 patients with chronic lymphocytic leukemia. For the majority of cases (25/31), we provide evidence of the co-existence of at least two B lymphocyte clones with a chronic lymphocytic leukemia phenotype. We also identified clonal drifts in serial samples, likely driven by selection forces.
dcterms:title
Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones
skos:prefLabel
Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones
skos:notation
RIV/00216224:14740/14:00077731!RIV15-MSM-14740___
n3:aktivita
n19:S n19:P
n3:aktivity
P(ED1.1.00/02.0068), P(EE2.3.20.0045), P(NT13493), S
n3:cisloPeriodika
2
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n6:5327903 n6:2093995 n6:4376285 n6:2030306 n6:1957864 n6:1248790 n6:3655083 n6:5761727 n6:7997825 n6:9811524
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
31091
n3:idVysledku
RIV/00216224:14740/14:00077731
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Chronic lymphocytic leukemia; immunoglobulin; B lymphocyte
n3:klicoveSlovo
n12:Chronic%20lymphocytic%20leukemia n12:immunoglobulin n12:B%20lymphocyte
n3:kodStatuVydavatele
IT - Italská republika
n3:kontrolniKodProRIV
[D5EBC1BFB6D5]
n3:nazevZdroje
Haematologica
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
10
n3:projekt
n4:ED1.1.00%2F02.0068 n4:NT13493 n4:EE2.3.20.0045
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
99
n3:tvurceVysledku
Tichý, Boris Pavlová, Šárka Plevová, Karla Brychtová, Yvona Burčková, Kateřina Doubek, Michael Skuhrová Francová, Hana Malčíková, Jitka Mayer, Jiří Pospíšilová, Šárka
n3:wos
000336253900026
s:issn
0390-6078
s:numberOfPages
10
n11:doi
10.3324/haematol.2013.087593
n7:organizacniJednotka
14740