This HTML5 document contains 55 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n20http://localhost/temp/predkladatel/
n19http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n15http://linked.opendata.cz/resource/domain/vavai/projekt/
n8http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n11http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n9http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14740%2F14%3A00076810%21RIV15-MSM-14740___/
n6http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00076810%21RIV15-MSM-14740___
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://nar.oxfordjournals.org/content/early/2014/05/29/nar.gku338
dcterms:description
A-tracts are functionally important DNA sequences which induce helix bending and have peculiar structural properties. While A-tract structure has been qualitatively well characterized, their mechanical properties remain controversial. A-tracts appear structurally rigid and resist nucleosome formation, but seem flexible in DNA looping. In this work, we investigate mechanical properties of symmetric A(n)T(n) and asymmetric A(2n) tracts for n = 3, 4, 5 using two types of coarse-grained models. The first model represents DNA as an ensemble of interacting rigid bases with non-local quadratic deformation energy, the second one treats DNA as an anisotropically bendable and twistable elastic rod. Parameters for both models are inferred from microsecond long, atomic-resolution molecular dynamics simulations. A-tracts are functionally important DNA sequences which induce helix bending and have peculiar structural properties. While A-tract structure has been qualitatively well characterized, their mechanical properties remain controversial. A-tracts appear structurally rigid and resist nucleosome formation, but seem flexible in DNA looping. In this work, we investigate mechanical properties of symmetric A(n)T(n) and asymmetric A(2n) tracts for n = 3, 4, 5 using two types of coarse-grained models. The first model represents DNA as an ensemble of interacting rigid bases with non-local quadratic deformation energy, the second one treats DNA as an anisotropically bendable and twistable elastic rod. Parameters for both models are inferred from microsecond long, atomic-resolution molecular dynamics simulations.
dcterms:title
Mechanical properties of symmetric and asymmetric DNA A-tracts: implications for looping and nucleosome positioning Mechanical properties of symmetric and asymmetric DNA A-tracts: implications for looping and nucleosome positioning
skos:prefLabel
Mechanical properties of symmetric and asymmetric DNA A-tracts: implications for looping and nucleosome positioning Mechanical properties of symmetric and asymmetric DNA A-tracts: implications for looping and nucleosome positioning
skos:notation
RIV/00216224:14740/14:00076810!RIV15-MSM-14740___
n4:aktivita
n12:I n12:P
n4:aktivity
I, P(ED1.1.00/02.0068), P(ED2.1.00/03.0058), P(GA14-21893S)
n4:cisloPeriodika
11
n4:dodaniDat
n6:2015
n4:domaciTvurceVysledku
n19:3223779
n4:druhVysledku
n16:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
28081
n4:idVysledku
RIV/00216224:14740/14:00076810
n4:jazykVysledku
n18:eng
n4:klicovaSlova
MOLECULAR-DYNAMICS SIMULATIONS; SEQUENCE-DIRECTED CURVATURE; ADENINE-THYMINE TRACT; BASE-PAIR LEVEL; INDIRECT READOUT; NUCLEIC-ACIDS; B-DNA; CONFORMATIONAL-ANALYSIS; DISFAVORING SEQUENCES; ELASTIC PROPERTIES
n4:klicoveSlovo
n7:BASE-PAIR%20LEVEL n7:INDIRECT%20READOUT n7:NUCLEIC-ACIDS n7:B-DNA n7:SEQUENCE-DIRECTED%20CURVATURE n7:ADENINE-THYMINE%20TRACT n7:DISFAVORING%20SEQUENCES n7:CONFORMATIONAL-ANALYSIS n7:MOLECULAR-DYNAMICS%20SIMULATIONS n7:ELASTIC%20PROPERTIES
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[FF71F6F47581]
n4:nazevZdroje
Nucleic Acids Research
n4:obor
n17:CF
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:projekt
n15:ED2.1.00%2F03.0058 n15:ED1.1.00%2F02.0068 n15:GA14-21893S
n4:rokUplatneniVysledku
n6:2014
n4:svazekPeriodika
42
n4:tvurceVysledku
Jurečka, Petr Šponer, Jiří Lankaš, Filip Špačková, Naďa Drsata, Tomáš Zgarbová, Marie
n4:wos
000338769400055
s:issn
0305-1048
s:numberOfPages
12
n11:doi
10.1093/nar/gku338
n20:organizacniJednotka
14740