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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00075743%21RIV15-MSM-14740___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://mct.aacrjournals.org/content/13/4/812.long
dcterms:description
The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling. The inhibitory effect of monensin on the Wnt/beta-catenin signaling cascade was observed in mammalian cells stimulated with Wnt ligands, glycogen synthase kinase-3 inhibitors, and in cells transfected with beta-catenin expression constructs. Furthermore, monensin suppressed the Wnt-dependent tail fin regeneration in zebrafish and Wnt- or beta-catenin-induced formation of secondary body axis in Xenopus embryos. In Wnt3a-activated HEK293 cells, monensin blocked the phoshorylation of Wnt coreceptor low-density lipoprotein receptor related protein 6 and promoted its degradation. The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling. The inhibitory effect of monensin on the Wnt/beta-catenin signaling cascade was observed in mammalian cells stimulated with Wnt ligands, glycogen synthase kinase-3 inhibitors, and in cells transfected with beta-catenin expression constructs. Furthermore, monensin suppressed the Wnt-dependent tail fin regeneration in zebrafish and Wnt- or beta-catenin-induced formation of secondary body axis in Xenopus embryos. In Wnt3a-activated HEK293 cells, monensin blocked the phoshorylation of Wnt coreceptor low-density lipoprotein receptor related protein 6 and promoted its degradation.
dcterms:title
Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice
skos:prefLabel
Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice
skos:notation
RIV/00216224:14740/14:00075743!RIV15-MSM-14740___
n4:aktivita
n19:S n19:P n19:I
n4:aktivity
I, P(ED1.1.00/02.0068), P(FR-TI4/802), P(GAP305/12/2347), P(LM2011022), P(LO1220), S
n4:cisloPeriodika
4
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
n14:4568567
n4:druhVysledku
n20:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
30344
n4:idVysledku
RIV/00216224:14740/14:00075743
n4:jazykVysledku
n8:eng
n4:klicovaSlova
BETA-CATENIN; CYCLE ARREST; COLON-CANCER; CARCINOMA-CELLS; LEUKEMIA-CELLS; IN-VIVO; APOPTOSIS; ACTIVATION; APC; GENES
n4:klicoveSlovo
n5:CYCLE%20ARREST n5:IN-VIVO n5:APOPTOSIS n5:ACTIVATION n5:CARCINOMA-CELLS n5:COLON-CANCER n5:GENES n5:APC n5:BETA-CATENIN n5:LEUKEMIA-CELLS
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[06514E1E5A2A]
n4:nazevZdroje
Molecular Cancer Therapeutics
n4:obor
n18:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
14
n4:projekt
n7:FR-TI4%2F802 n7:LO1220 n7:ED1.1.00%2F02.0068 n7:GAP305%2F12%2F2347 n7:LM2011022
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
13
n4:tvurceVysledku
Šloncová, Eva Bartůněk, Petr Gradl, Dietmar Horázná, Monika Jindřich, Jindřich Kořínek, Vladimír Krausová, Michaela Stančíková, Jitka Tůmová, Lucie Pombinho, Antonio Vojtěchová, Martina Machoňová, Olga Zdráhal, Zbyněk Kříž, Vítězslav
n4:wos
000334342300005
s:issn
1535-7163
s:numberOfPages
11
n15:doi
10.1158/1535-7163.MCT-13-0625
n10:organizacniJednotka
14740