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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00075373%21RIV15-MSM-14740___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00130/full
dcterms:description
A number of studies demonstrated a rapid onset of an antidepressant effect of non-competitive N-methyl-d-aspartic acid receptor (NMDAR) antagonists. Nonetheless, its therapeutic potential is rather limited, due to a high coincidence of negative side-effects. Therefore, the challenge seems to be in the development of NMDAR antagonists displaying antidepressant properties, and at the same time maintaining regular physiological function of the NMDAR. Previous results demonstrated that naturally occurring neurosteroid 3alfa5beta-pregnanolone sulfate shows pronounced inhibitory action by a use-dependent mechanism on the tonically active NMDAR. The aim of the present experiments is to find out whether the treatment with pregnanolone 3alfaC derivatives affects behavioral response to chronic and acute stress in an animal model of depression. Adult male mice were used throughout the study. Repeated social defeat and forced swimming tests were used as animal models of depression. A number of studies demonstrated a rapid onset of an antidepressant effect of non-competitive N-methyl-d-aspartic acid receptor (NMDAR) antagonists. Nonetheless, its therapeutic potential is rather limited, due to a high coincidence of negative side-effects. Therefore, the challenge seems to be in the development of NMDAR antagonists displaying antidepressant properties, and at the same time maintaining regular physiological function of the NMDAR. Previous results demonstrated that naturally occurring neurosteroid 3alfa5beta-pregnanolone sulfate shows pronounced inhibitory action by a use-dependent mechanism on the tonically active NMDAR. The aim of the present experiments is to find out whether the treatment with pregnanolone 3alfaC derivatives affects behavioral response to chronic and acute stress in an animal model of depression. Adult male mice were used throughout the study. Repeated social defeat and forced swimming tests were used as animal models of depression.
dcterms:title
Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models
skos:prefLabel
Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models
skos:notation
RIV/00216224:14740/14:00075373!RIV15-MSM-14740___
n3:aktivita
n16:S n16:P n16:I
n3:aktivity
I, P(ED1.1.00/02.0068), P(GAP303/12/1464), P(GBP304/12/G069), P(LM2011017), P(TE01020028), S
n3:cisloPeriodika
April
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n7:3007251 n7:6157181
n3:druhVysledku
n14:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
38895
n3:idVysledku
RIV/00216224:14740/14:00075373
n3:jazykVysledku
n9:eng
n3:klicovaSlova
pregnanolone glutamate; NMDAR; anxiolytic-like properties; antidepressant-like properties
n3:klicoveSlovo
n15:pregnanolone%20glutamate n15:anxiolytic-like%20properties n15:NMDAR n15:antidepressant-like%20properties
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[A4CA3284A180]
n3:nazevZdroje
Frontiers in Behavioral Neuroscience
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n5:ED1.1.00%2F02.0068 n5:GBP304%2F12%2FG069 n5:TE01020028 n5:LM2011017 n5:GAP303%2F12%2F1464
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
8
n3:tvurceVysledku
Šulcová, Alexandra Nekovarova, Tereza Stuchlik, Ales Holubova, Kristina Vales, Karel Pistovčáková, Jana
n3:wos
000334289800001
s:issn
1662-5153
s:numberOfPages
10
n6:doi
10.3389/fnbeh.2014.00130
n20:organizacniJednotka
14740