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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00074403%21RIV15-MSM-14740___
rdf:type
n18:Vysledek skos:Concept
rdfs:seeAlso
http://genesdev.cshlp.org/content/early/2014/10/23/gad.251611.114.full.pdf+html
dcterms:description
The semiconservative replication of telomeres is facilitated by the shelterin component TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon S-phase progression, fragile metaphase telomeres that resemble the common fragile sites (CFSs), and the association of sister telomeres. In contrast, TRF1 does not contribute significantly to the end protection functions of shelterin. We addressed the mechanism of TRF1 action using mouse conditional knockouts of BLM, TRF1, TPP1, and Rap1 in combination with expression of TRF1 and TIN2 mutants. The data establish that TRF1 binds BLM to facilitate lagging but not leading strand telomeric DNA synthesis. As the template for lagging strand telomeric DNA synthesis is the TTAGGG repeat strand, TRF1-bound BLM is likely required to remove secondary structures formed by these sequences. The semiconservative replication of telomeres is facilitated by the shelterin component TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon S-phase progression, fragile metaphase telomeres that resemble the common fragile sites (CFSs), and the association of sister telomeres. In contrast, TRF1 does not contribute significantly to the end protection functions of shelterin. We addressed the mechanism of TRF1 action using mouse conditional knockouts of BLM, TRF1, TPP1, and Rap1 in combination with expression of TRF1 and TIN2 mutants. The data establish that TRF1 binds BLM to facilitate lagging but not leading strand telomeric DNA synthesis. As the template for lagging strand telomeric DNA synthesis is the TTAGGG repeat strand, TRF1-bound BLM is likely required to remove secondary structures formed by these sequences.
dcterms:title
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling
skos:prefLabel
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling
skos:notation
RIV/00216224:14740/14:00074403!RIV15-MSM-14740___
n3:aktivita
n20:P
n3:aktivity
P(ED1.1.00/02.0068), P(GAP205/12/0550)
n3:cisloPeriodika
22
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n12:9928758
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
51240
n3:idVysledku
RIV/00216224:14740/14:00074403
n3:jazykVysledku
n15:eng
n3:klicovaSlova
telomere; shelterin; TRF1; BLM; replication; G quadruplex
n3:klicoveSlovo
n14:G%20quadruplex n14:BLM n14:replication n14:shelterin n14:TRF1 n14:telomere
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[AE905037A33A]
n3:nazevZdroje
GENES & DEVELOPMENT
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n10:ED1.1.00%2F02.0068 n10:GAP205%2F12%2F0550
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
28
n3:tvurceVysledku
Zimmermann, Michal Kabir, S. de Lange, T. Kibe, T.
n3:wos
000345269300005
s:issn
0890-9369
s:numberOfPages
15
n9:doi
10.1101/gad.251611.114
n16:organizacniJednotka
14740