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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00074325%21RIV15-MSM-14740___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
dcterms:description
The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages.
dcterms:title
Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects
skos:prefLabel
Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects
skos:notation
RIV/00216224:14740/14:00074325!RIV15-MSM-14740___
n5:aktivita
n6:P
n5:aktivity
P(ED1.1.00/02.0068), P(GA14-33143S)
n5:cisloPeriodika
10
n5:dodaniDat
n16:2015
n5:domaciTvurceVysledku
n8:6033040 n8:3561119 n8:7325401 n8:6071236
n5:druhVysledku
n7:J
n5:duvernostUdaju
n10:S
n5:entitaPredkladatele
n12:predkladatel
n5:idSjednocenehoVysledku
11773
n5:idVysledku
RIV/00216224:14740/14:00074325
n5:jazykVysledku
n19:eng
n5:klicovaSlova
Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment
n5:klicoveSlovo
n9:Functional%20connectivity n9:Alzheimer%27s%20disease n9:Resting%20state n9:Resting%20state%20networks n9:Mild%20cognitive%20impairment n9:fMRI n9:Default%20mode%20network
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[483C98E3BFA3]
n5:nazevZdroje
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
n5:obor
n11:FH
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
4
n5:projekt
n15:ED1.1.00%2F02.0068 n15:GA14-33143S
n5:rokUplatneniVysledku
n16:2014
n5:svazekPeriodika
14
n5:tvurceVysledku
Krajčovičová, Lenka Mareček, Radek Mikl, Michal Rektorová, Irena
n5:wos
000342073900008
s:issn
1528-4042
s:numberOfPages
7
n14:doi
10.1007/s11910-014-0491-3
n20:organizacniJednotka
14740