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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00073973%21RIV15-MSM-14740___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/25233930
dcterms:description
Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-delta(TNF-delta) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Here, we extend those studies by describing a novel mechanism participating in the regulation of CYP1B1 expression, which involves activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1). Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38delta-deficient and MSK1/2 double knockout mice, we show here that TNF-delta potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade. Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-delta(TNF-delta) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Here, we extend those studies by describing a novel mechanism participating in the regulation of CYP1B1 expression, which involves activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1). Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38delta-deficient and MSK1/2 double knockout mice, we show here that TNF-delta potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade.
dcterms:title
Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway
skos:prefLabel
Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway
skos:notation
RIV/00216224:14740/14:00073973!RIV15-MSM-14740___
n4:aktivita
n8:Z n8:P
n4:aktivity
P(ED1.1.00/02.0068), P(EE2.3.30.0030), P(GA14-09979S), P(GAP503/11/1227), Z(MZE0002716202)
n4:cisloPeriodika
11
n4:dodaniDat
n19:2015
n4:domaciTvurceVysledku
n14:8503222 n14:8886520 n14:2515784
n4:druhVysledku
n11:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
52125
n4:idVysledku
RIV/00216224:14740/14:00073973
n4:jazykVysledku
n17:eng
n4:klicovaSlova
CYP1B1; inflammation; p38 MAP kinase; MSK; metabolism of carcinogens
n4:klicoveSlovo
n12:p38%20MAP%20kinase n12:CYP1B1 n12:inflammation n12:MSK n12:metabolism%20of%20carcinogens
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[98F87E081494]
n4:nazevZdroje
Carcinogenesis
n4:obor
n13:EB
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
7
n4:projekt
n6:GA14-09979S n6:EE2.3.30.0030 n6:GAP503%2F11%2F1227 n6:ED1.1.00%2F02.0068
n4:rokUplatneniVysledku
n19:2014
n4:svazekPeriodika
35
n4:tvurceVysledku
Machala, Miroslav Šmerdová, Lenka Kabátková, Markéta Vondráček, Jan Blažek, Dalibor Svobodová, Jana Kohoutek, Jiří
n4:wos
000345835800017
n4:zamer
n15:MZE0002716202
s:issn
0143-3334
s:numberOfPages
10
n20:doi
10.1093/carcin/bgu190
n18:organizacniJednotka
14740