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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00073917%21RIV15-MSM-14740___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://pubs.acs.org/doi/abs/10.1021/jp5030685
dcterms:description
The mRNA decoding site (A-site) in the small ribosomal subunit controls fidelity of the translation process. Here, using molecular dynamics simulations and bioinformatic analyses, we investigated the structural dynamics of the human mitochondrial A-site (native and A1490G mutant) and compared it with the dynamics of the bacterial A-site. We detected and characterized a specific RNA backbone configuration, S-turn2, which occurs in the human mitochondrial but not in the bacterial A-site. Mitochondrial and bacterial A-sites show different propensities to form S-turn2 that may be caused by different base-pairing patterns of the flanking nucleotides. Also, the S-tum2 structural stability observed in the simulations supports higher accuracy and lower speed of mRNA decoding in mitochondria in comparison with bacteria. The mRNA decoding site (A-site) in the small ribosomal subunit controls fidelity of the translation process. Here, using molecular dynamics simulations and bioinformatic analyses, we investigated the structural dynamics of the human mitochondrial A-site (native and A1490G mutant) and compared it with the dynamics of the bacterial A-site. We detected and characterized a specific RNA backbone configuration, S-turn2, which occurs in the human mitochondrial but not in the bacterial A-site. Mitochondrial and bacterial A-sites show different propensities to form S-turn2 that may be caused by different base-pairing patterns of the flanking nucleotides. Also, the S-tum2 structural stability observed in the simulations supports higher accuracy and lower speed of mRNA decoding in mitochondria in comparison with bacteria.
dcterms:title
Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study
skos:prefLabel
Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study
skos:notation
RIV/00216224:14740/14:00073917!RIV15-MSM-14740___
n3:aktivita
n19:P n19:I
n3:aktivity
I, P(ED1.1.00/02.0068), P(GBP305/12/G034)
n3:cisloPeriodika
24
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n7:6410715 n7:3223779 n7:9031510
n3:druhVysledku
n20:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
43194
n3:idVysledku
RIV/00216224:14740/14:00073917
n3:jazykVysledku
n17:eng
n3:klicovaSlova
NUCLEIC-ACIDS; DECODING SITE; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; RNA STRUCTURE; MINOR MOTIF; FORCE-FIELD; BASE-PAIRS; BINDING; SUBUNIT
n3:klicoveSlovo
n5:BASE-PAIRS n5:DECODING%20SITE n5:SUBUNIT n5:RNA%20STRUCTURE n5:FORCE-FIELD n5:MINOR%20MOTIF n5:ESCHERICHIA-COLI n5:BINDING n5:CRYSTAL-STRUCTURE n5:NUCLEIC-ACIDS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[1E1F837D739D]
n3:nazevZdroje
Journal of Physical Chemistry B
n3:obor
n13:CF
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n10:GBP305%2F12%2FG034 n10:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
118
n3:tvurceVysledku
Šponer, Jiří Trylska, Joanna Havrila, Marek Réblová, Kamila Panecka, Joanna
n3:wos
000337784100037
s:issn
1520-6106
s:numberOfPages
15
n9:doi
10.1021/jp5030685
n14:organizacniJednotka
14740