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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F14%3A00073857%21RIV15-MSM-14740___
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://pubs.acs.org/doi/abs/10.1021/ja505502e
dcterms:description
The presence of surfaces influences the fibril formation kinetics of peptides and proteins. We present a systematic study of the aggregation kinetics of amyloidogenic peptides caused by different surfaces using molecular simulations of model peptides and thioflavin T fluorescence experiments. Increasing the monomer surface attraction affects the nucleation and growth of small oligomers in a nonlinear manner: Weakly attractive surfaces lead to retardation; strongly attractive surfaces lead to acceleration. Further, the same type of surface either accelerates or retards growth, depending on the bulk propensity of the peptide to form fibrils: An attractive surface retards fibril formation of peptides with a high tendency for fibril formation, while the same surface accelerates fibril formation of peptides with a low propensity for fibril formation. The presence of surfaces influences the fibril formation kinetics of peptides and proteins. We present a systematic study of the aggregation kinetics of amyloidogenic peptides caused by different surfaces using molecular simulations of model peptides and thioflavin T fluorescence experiments. Increasing the monomer surface attraction affects the nucleation and growth of small oligomers in a nonlinear manner: Weakly attractive surfaces lead to retardation; strongly attractive surfaces lead to acceleration. Further, the same type of surface either accelerates or retards growth, depending on the bulk propensity of the peptide to form fibrils: An attractive surface retards fibril formation of peptides with a high tendency for fibril formation, while the same surface accelerates fibril formation of peptides with a low propensity for fibril formation.
dcterms:title
Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides
skos:prefLabel
Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides
skos:notation
RIV/00216224:14740/14:00073857!RIV15-MSM-14740___
n3:aktivita
n20:P
n3:aktivity
P(ED1.1.00/02.0068), P(GA14-12598S)
n3:cisloPeriodika
33
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n8:7712200
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
48631
n3:idVysledku
RIV/00216224:14740/14:00073857
n3:jazykVysledku
n9:eng
n3:klicovaSlova
BETA PROTEIN FIBRILLATION; ALPHA-SYNUCLEIN; POLYMERIC NANOPARTICLES; MEMBRANE INTERACTIONS; LIPID-BILAYERS; DRUG-DELIVERY; PHASE; NUCLEATION; INHIBITION; INTERFACES
n3:klicoveSlovo
n4:DRUG-DELIVERY n4:POLYMERIC%20NANOPARTICLES n4:NUCLEATION n4:BETA%20PROTEIN%20FIBRILLATION n4:ALPHA-SYNUCLEIN n4:INTERFACES n4:LIPID-BILAYERS n4:INHIBITION n4:PHASE n4:MEMBRANE%20INTERACTIONS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[31019671F66A]
n3:nazevZdroje
Journal of the American Chemical Society
n3:obor
n11:CF
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n12:ED1.1.00%2F02.0068 n12:GA14-12598S
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
136
n3:tvurceVysledku
Linse, S. Vácha, Robert Lund, M.
n3:wos
000340737900033
s:issn
0002-7863
s:numberOfPages
7
n19:doi
10.1021/ja505502e
n18:organizacniJednotka
14740