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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F13%3A00072706%21RIV14-MSM-14740___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Carbohydrates play a pivotal role in a plethora of the biological processes as they are ubiquitously present in all cells in the variety of forms such as glycoproteins, proteoglycans and glycolipids collectively called as glyco-conjugates. Glyco-conjugates carry the necessary information for cell-cell recognition1 and their function is quite diverse and vital for the cell. These glyco-conjugates are formed by the sequential action of glycosyltransferases (GTase) which add saccharides onto proteins, lipids etc.2 Our present study is focused on the exploring the reaction mechanisms of O-GlcNAcylation process, where GlcNAc is transferred to –OH group of Ser/Thr of the proteins. The aim of the study is to find the most probable reaction pathways and corresponding transition states. Several mechanisms for the OGT glycosyltransferase are already proposed on similar systems (Figure 1). Carbohydrates play a pivotal role in a plethora of the biological processes as they are ubiquitously present in all cells in the variety of forms such as glycoproteins, proteoglycans and glycolipids collectively called as glyco-conjugates. Glyco-conjugates carry the necessary information for cell-cell recognition1 and their function is quite diverse and vital for the cell. These glyco-conjugates are formed by the sequential action of glycosyltransferases (GTase) which add saccharides onto proteins, lipids etc.2 Our present study is focused on the exploring the reaction mechanisms of O-GlcNAcylation process, where GlcNAc is transferred to –OH group of Ser/Thr of the proteins. The aim of the study is to find the most probable reaction pathways and corresponding transition states. Several mechanisms for the OGT glycosyltransferase are already proposed on similar systems (Figure 1).
dcterms:title
Exploring the reaction mechanism for OGT glycosyltransferase using QM/MM molecular dynamics Exploring the reaction mechanism for OGT glycosyltransferase using QM/MM molecular dynamics
skos:prefLabel
Exploring the reaction mechanism for OGT glycosyltransferase using QM/MM molecular dynamics Exploring the reaction mechanism for OGT glycosyltransferase using QM/MM molecular dynamics
skos:notation
RIV/00216224:14740/13:00072706!RIV14-MSM-14740___
n15:predkladatel
n16:orjk%3A14740
n4:aktivita
n9:R
n4:aktivity
R
n4:dodaniDat
n10:2014
n4:domaciTvurceVysledku
n6:8988250 Kumari, Manju n6:4347374
n4:druhVysledku
n12:O
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
74320
n4:idVysledku
RIV/00216224:14740/13:00072706
n4:jazykVysledku
n17:eng
n4:klicovaSlova
glycosyltransferases; qmmm; reaction mechanism; cpmd
n4:klicoveSlovo
n5:qmmm n5:glycosyltransferases n5:reaction%20mechanism n5:cpmd
n4:kontrolniKodProRIV
[52BD8AD5E2F9]
n4:obor
n13:CF
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n10:2013
n4:tvurceVysledku
Koča, Jaroslav Kozmon, Stanislav Kumari, Manju Tvaroška, Igor
n8:organizacniJednotka
14740