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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F13%3A00069968%21RIV14-MSM-14740___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/jon.12030/pdf
dcterms:description
The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength. The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength.
dcterms:title
Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing
skos:prefLabel
Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing
skos:notation
RIV/00216224:14740/13:00069968!RIV14-MSM-14740___
n14:predkladatel
n15:orjk%3A14740
n5:aktivita
n18:P
n5:aktivity
P(ED1.1.00/02.0068)
n5:cisloPeriodika
4
n5:dodaniDat
n9:2014
n5:domaciTvurceVysledku
n8:2673517 n8:6185134 n8:8298327 n8:7325401 n8:3561119
n5:druhVysledku
n13:J
n5:duvernostUdaju
n21:S
n5:entitaPredkladatele
n7:predkladatel
n5:idSjednocenehoVysledku
105100
n5:idVysledku
RIV/00216224:14740/13:00069968
n5:jazykVysledku
n12:eng
n5:klicovaSlova
Basal ganglia; Parkinson's disease; cerebellum; connectivity; cortical reorganization; motor timing; prediction; supplementary motor area
n5:klicoveSlovo
n6:Basal%20ganglia n6:prediction n6:supplementary%20motor%20area n6:Parkinson%27s%20disease n6:motor%20timing n6:cerebellum n6:connectivity n6:cortical%20reorganization
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[B39CCEF4EB9E]
n5:nazevZdroje
Journal of Neuroimaging
n5:obor
n11:FH
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
6
n5:projekt
n20:ED1.1.00%2F02.0068
n5:rokUplatneniVysledku
n9:2013
n5:svazekPeriodika
23
n5:tvurceVysledku
Mareček, Radek Husárová, Ivica Bareš, Martin Mikl, Michal Vaníček, Jiří Lungu, Ovidiu V.
s:issn
1051-2284
s:numberOfPages
11
n17:doi
10.1111/jon.12030
n16:organizacniJednotka
14740