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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F13%3A00066446%21RIV14-MSM-14740___
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://rnajournal.cshlp.org/content/early/2013/10/18/rna.040055.113.abstract
dcterms:description
The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3'uridylation via LIN28A-TUT4/7 has been recognized as an essential component controlling the biogenesis of let-7 miRNAs in stem cells. Although uridylation has been generally implicated in miRNA degradation, the nuclease responsible has remained unknown. Here, we identify the Perlman syndromeassociated protein DIS3L2 as an oligo(U)-binding and processing exoribonuclease that specifically targets uridylated pre-let-7 in vivo. This study establishes DIS3L2 as the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3'uridylation via LIN28A-TUT4/7 has been recognized as an essential component controlling the biogenesis of let-7 miRNAs in stem cells. Although uridylation has been generally implicated in miRNA degradation, the nuclease responsible has remained unknown. Here, we identify the Perlman syndromeassociated protein DIS3L2 as an oligo(U)-binding and processing exoribonuclease that specifically targets uridylated pre-let-7 in vivo. This study establishes DIS3L2 as the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells.
dcterms:title
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
skos:prefLabel
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
skos:notation
RIV/00216224:14740/13:00066446!RIV14-MSM-14740___
n12:predkladatel
n21:orjk%3A14740
n3:aktivita
n19:P
n3:aktivity
P(ED1.1.00/02.0068), P(GAP305/11/1095), P(GBP206/12/G151), P(GBP305/12/G034)
n3:cisloPeriodika
12
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n5:6215750 n5:8751250 n5:4568567 n5:6563902 n5:6824226 n5:9185917 n5:5234360 n5:3019519 n5:6655394 n5:7024061
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
85868
n3:idVysledku
RIV/00216224:14740/13:00066446
n3:jazykVysledku
n20:eng
n3:klicovaSlova
DIS3L2; RNA degradation; RNA uridylation; let-7 miRNA
n3:klicoveSlovo
n10:RNA%20uridylation n10:RNA%20degradation n10:DIS3L2 n10:let-7%20miRNA
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[39EC27C33F22]
n3:nazevZdroje
RNA
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
10
n3:projekt
n4:GBP305%2F12%2FG034 n4:GBP206%2F12%2FG151 n4:GAP305%2F11%2F1095 n4:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
19
n3:tvurceVysledku
Vaňáčová, Štěpánka Uldrijan, Stjepan Hrazdilová, Kristýna Potěšil, David Zdráhal, Zbyněk Ustianenko, Dmytro Hroššová, Dominika Chalupníková, Kateřina Pacherník, Jiří Cetkovská, Kateřina
n3:wos
000327445700004
s:issn
1355-8382
s:numberOfPages
7
n18:doi
10.1261/rna.040055.113
n14:organizacniJednotka
14740