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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F13%3A00065597%21RIV14-MZ0-14740___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
MicroRNAs (miRNAs) are small non-coding RNAs 18–25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs’ occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection. MicroRNAs (miRNAs) are small non-coding RNAs 18–25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs’ occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection.
dcterms:title
MicroRNAs in solid cancer: from biomarkers to therapeutic targets MicroRNAs in solid cancer: from biomarkers to therapeutic targets
skos:prefLabel
MicroRNAs in solid cancer: from biomarkers to therapeutic targets MicroRNAs in solid cancer: from biomarkers to therapeutic targets
skos:notation
RIV/00216224:14740/13:00065597!RIV14-MZ0-14740___
n10:predkladatel
n14:orjk%3A14740
n4:aktivita
n7:P
n4:aktivity
P(NT13514), P(NT13549)
n4:dodaniDat
n8:2014
n4:domaciTvurceVysledku
n18:5974291
n4:druhVysledku
n9:O
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
88205
n4:idVysledku
RIV/00216224:14740/13:00065597
n4:jazykVysledku
n15:eng
n4:klicovaSlova
microRNAs; solid cancers; biomarkers; therapeutic targets
n4:klicoveSlovo
n5:biomarkers n5:therapeutic%20targets n5:microRNAs n5:solid%20cancers
n4:kontrolniKodProRIV
[8C5EBDEF1829]
n4:obor
n11:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
1
n4:projekt
n17:NT13514 n17:NT13549
n4:rokUplatneniVysledku
n8:2013
n4:tvurceVysledku
Slabý, Ondřej
n13:organizacniJednotka
14740