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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F13%3A00065596%21RIV14-MZ0-14740___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM. Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM.
dcterms:title
Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma
skos:prefLabel
Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma
skos:notation
RIV/00216224:14740/13:00065596!RIV14-MZ0-14740___
n7:predkladatel
n8:orjk%3A14740
n3:aktivita
n16:P
n3:aktivity
P(ED1.1.00/02.0068), P(NT13514)
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n10:6728472 n10:7931883 n10:5974291 n10:6231616
n3:druhVysledku
n15:O
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
74343
n3:idVysledku
RIV/00216224:14740/13:00065596
n3:jazykVysledku
n14:eng
n3:klicovaSlova
microRNA; chemoresistance; radioresistance; glioblastoma multiforme
n3:klicoveSlovo
n9:glioblastoma%20multiforme n9:radioresistance n9:microRNA n9:chemoresistance
n3:kontrolniKodProRIV
[1AC6274BC793]
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n13:NT13514 n13:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n4:2013
n3:tvurceVysledku
Vyzula, Rostislav Šána, Jiří Kosařová, Zdeňka Slabý, Ondřej Bešše, Andrej Lakomý, Radek Smrčka, Martin
n11:organizacniJednotka
14740