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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F13%3A00065588%21RIV14-MZ0-14740___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response.
dcterms:title
MicroRNAs involved in chemo- and radioresistance of high-grade gliomas MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
skos:prefLabel
MicroRNAs involved in chemo- and radioresistance of high-grade gliomas MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
skos:notation
RIV/00216224:14740/13:00065588!RIV14-MZ0-14740___
n12:predkladatel
n13:orjk%3A14740
n3:aktivita
n4:P
n3:aktivity
P(ED1.1.00/02.0068), P(NT13514)
n3:cisloPeriodika
4
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n9:6231616 n9:6728472 n9:5974291 n9:3479714
n3:druhVysledku
n19:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
88207
n3:idVysledku
RIV/00216224:14740/13:00065588
n3:jazykVysledku
n17:eng
n3:klicovaSlova
microRNA; chemoresistance; radioresistance; high-grade gliomas
n3:klicoveSlovo
n11:radioresistance n11:chemoresistance n11:high-grade%20gliomas n11:microRNA
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[2B5FF6C63CA6]
n3:nazevZdroje
Tumor Biology
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n8:NT13514 n8:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
34
n3:tvurceVysledku
Fadrus, Pavel Šána, Jiří Slabý, Ondřej Bešše, Andrej
n3:wos
000321912500001
s:issn
1010-4283
s:numberOfPages
10
n20:doi
10.1007/s13277-013-0772-5
n16:organizacniJednotka
14740