This HTML5 document contains 57 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n13http://localhost/temp/predkladatel/
n5http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n4http://linked.opendata.cz/resource/domain/vavai/projekt/
n20http://linked.opendata.cz/resource/domain/vavai/subjekt/
n14http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n7http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n6http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14740%2F12%3A00060968%21RIV13-MSM-14740___/
xsdhhttp://www.w3.org/2001/XMLSchema#
n21http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n11http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F12%3A00060968%21RIV13-MSM-14740___
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://pubs.rsc.org/en/Content/ArticleLanding/2012/MB/c2mb25136a
dcterms:description
Overexpression of histone deacetylases (HDACs), with consequent hypoacetylation of histones, is reportedly associated with transcriptional repression of tumour suppressor genes. Thus, inhibition of HDACs has emerged as a promising strategy in cancer therapy. In order to monitor the effects of potential HDAC inhibitors, a multi-level approach consisting of preliminary screening (measurement of HDAC activity and semi-quantitative evaluation of histone H4 modification profile by MALDI-TOF MS) and detailed analysis of histone modification forms (using 2-D AUT/AU PAGE and LC-ESI-IT MS) has been used in this study. The data obtained provide a global insight into the effects of HDAC inhibitors on the histone acetylation status that participates in gene transcription control. Overexpression of histone deacetylases (HDACs), with consequent hypoacetylation of histones, is reportedly associated with transcriptional repression of tumour suppressor genes. Thus, inhibition of HDACs has emerged as a promising strategy in cancer therapy. In order to monitor the effects of potential HDAC inhibitors, a multi-level approach consisting of preliminary screening (measurement of HDAC activity and semi-quantitative evaluation of histone H4 modification profile by MALDI-TOF MS) and detailed analysis of histone modification forms (using 2-D AUT/AU PAGE and LC-ESI-IT MS) has been used in this study. The data obtained provide a global insight into the effects of HDAC inhibitors on the histone acetylation status that participates in gene transcription control.
dcterms:title
A combined approach for the study of histone deacetylase inhibitors A combined approach for the study of histone deacetylase inhibitors
skos:prefLabel
A combined approach for the study of histone deacetylase inhibitors A combined approach for the study of histone deacetylase inhibitors
skos:notation
RIV/00216224:14740/12:00060968!RIV13-MSM-14740___
n14:predkladatel
n20:orjk%3A14740
n3:aktivita
n16:P
n3:aktivity
P(2B08060), P(ED1.1.00/02.0068)
n3:cisloPeriodika
11
n3:dodaniDat
n11:2013
n3:domaciTvurceVysledku
n5:8202575 n5:3196178 n5:9725741 n5:1649671 n5:4568567 n5:6323685 n5:9227636 n5:4884167
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
120066
n3:idVysledku
RIV/00216224:14740/12:00060968
n3:jazykVysledku
n21:eng
n3:klicovaSlova
histone acetylation; inhibitors of histone deacetylases; MALDI-MS; LC-MS/MS
n3:klicoveSlovo
n6:LC-MS%2FMS n6:histone%20acetylation n6:inhibitors%20of%20histone%20deacetylases n6:MALDI-MS
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[37ECB5376C46]
n3:nazevZdroje
Molecular BioSystems
n3:obor
n10:CE
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:projekt
n4:ED1.1.00%2F02.0068 n4:2B08060
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
8
n3:tvurceVysledku
Šilerová, Pavla Fajkusová, Lenka Fajkus, Jiří Činčárová, Lenka Konečná, Hana Zdráhal, Zbyněk Nováková, Kateřina Lochmanová, Gabriela
n3:wos
000309481300017
s:issn
1742-206X
s:numberOfPages
9
n7:doi
10.1039/c2mb25136a
n13:organizacniJednotka
14740