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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F12%3A00057421%21RIV13-GA0-14740___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Cytosine-rich oligodeoxynucleotides (C-rich ODNs) play diverse roles in the regulation of protein expression at both transcriptional and translational levels. A repetitive C sequence can be responsible for some diseases. It is commonly known that C-rich ODNs form the stable i-motif structure, interesting due to a crucial role in the process of genetic information transfer. The aim of this contribution is to find out the relationship between the structure of homo-ODNs in buffered solutions with the same ionic strength (I = 0.18 M) but with a different number of cytosines (dCx; x = 3, 4, 5, 6, 9). Using linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS), electrochemical reduction signals studied on a mercury electrode reflect the conformation changes of the C-rich ODN chain. Cytosine-rich oligodeoxynucleotides (C-rich ODNs) play diverse roles in the regulation of protein expression at both transcriptional and translational levels. A repetitive C sequence can be responsible for some diseases. It is commonly known that C-rich ODNs form the stable i-motif structure, interesting due to a crucial role in the process of genetic information transfer. The aim of this contribution is to find out the relationship between the structure of homo-ODNs in buffered solutions with the same ionic strength (I = 0.18 M) but with a different number of cytosines (dCx; x = 3, 4, 5, 6, 9). Using linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS), electrochemical reduction signals studied on a mercury electrode reflect the conformation changes of the C-rich ODN chain.
dcterms:title
ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES
skos:prefLabel
ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES
skos:notation
RIV/00216224:14740/12:00057421!RIV13-GA0-14740___
n14:predkladatel
n15:orjk%3A14740
n3:aktivita
n18:P
n3:aktivity
P(ED1.1.00/02.0068), P(GD106/09/H035)
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n7:3790185 n7:6359922 n7:8637881 n7:1956817
n3:druhVysledku
n21:D
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
133888
n3:idVysledku
RIV/00216224:14740/12:00057421
n3:jazykVysledku
n19:eng
n3:klicovaSlova
cytosine; oligonucleotides; cyclic voltammetry; elimination voltammetry
n3:klicoveSlovo
n11:cytosine n11:elimination%20voltammetry n11:oligonucleotides n11:cyclic%20voltammetry
n3:kontrolniKodProRIV
[B55690131D6C]
n3:mistoKonaniAkce
Brno
n3:mistoVydani
Brno
n3:nazevZdroje
XII. Pracovní setkání fyzikálních chemiků a elektrochemiků
n3:obor
n22:CF
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n17:ED1.1.00%2F02.0068 n17:GD106%2F09%2FH035
n3:rokUplatneniVysledku
n10:2012
n3:tvurceVysledku
Balcarová, Zdeňka Pilařová, Iveta Gurecký, Libor Trnková, Libuše
n3:typAkce
n13:EUR
n3:zahajeniAkce
2012-01-01+01:00
s:numberOfPages
2
n16:hasPublisher
Mendelova zemědělská a lesnická univerzita v Brně
n8:isbn
9788073756185
n9:organizacniJednotka
14740