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Statements

Subject Item
n2:RIV%2F00216224%3A14740%2F11%3A00049500%21RIV12-GA0-14740___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Recently, we reported (Majerova et al. 2011) that hypomethylating drugs efficiently decrease methylation of telomeric DNA and activate telomerase without affecting telomere lengths in tobacco. The key issue of the Letter to Editor written by Vaquero-Sedas and Vega-Palas (2011) is, whether our results demonstrating methylation and druginduced hypomethylation of tobacco telomeric DNA repeats do correspond to the status of terminal telomeric sequences, or rather to internal telomeric sequences (ITSs) which might exist in tobacco genome as it is the case in Arabidopsis thaliana, the model organism which Vaquero- Sedas and Vega-Palas have been working with. They are referring to their recent article (Vaquero-Sedas et al. 2010) in which they conclude that ITSs in A. thaliana are heterochromatic, while telomeres are euchromatic. We are pleased that our paper has initiated this debate and take the opportunity to go through the key points of the Letter of Vaquero-Sedas and Vega-Palas Recently, we reported (Majerova et al. 2011) that hypomethylating drugs efficiently decrease methylation of telomeric DNA and activate telomerase without affecting telomere lengths in tobacco. The key issue of the Letter to Editor written by Vaquero-Sedas and Vega-Palas (2011) is, whether our results demonstrating methylation and druginduced hypomethylation of tobacco telomeric DNA repeats do correspond to the status of terminal telomeric sequences, or rather to internal telomeric sequences (ITSs) which might exist in tobacco genome as it is the case in Arabidopsis thaliana, the model organism which Vaquero- Sedas and Vega-Palas have been working with. They are referring to their recent article (Vaquero-Sedas et al. 2010) in which they conclude that ITSs in A. thaliana are heterochromatic, while telomeres are euchromatic. We are pleased that our paper has initiated this debate and take the opportunity to go through the key points of the Letter of Vaquero-Sedas and Vega-Palas
dcterms:title
Methylation of plant telomeric DNA: what do the results say? Methylation of plant telomeric DNA: what do the results say?
skos:prefLabel
Methylation of plant telomeric DNA: what do the results say? Methylation of plant telomeric DNA: what do the results say?
skos:notation
RIV/00216224:14740/11:00049500!RIV12-GA0-14740___
n19:predkladatel
n20:orjk%3A14740
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GA204/08/1530), P(IAA500040801), P(LC06035), Z(MSM0021622415)
n3:cisloPeriodika
6
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n7:1629239 n7:8202575 n7:3129888 n7:2175010
n3:druhVysledku
n13:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
211843
n3:idVysledku
RIV/00216224:14740/11:00049500
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Nicotiana tabacum; Cell culture Telomere; Hypomethylating agents; Zebularine; DNA methylation
n3:klicoveSlovo
n9:Hypomethylating%20agents n9:Zebularine n9:Cell%20culture%20Telomere n9:DNA%20methylation n9:Nicotiana%20tabacum
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[4FA0E667A758]
n3:nazevZdroje
Plant Molecular Biology
n3:obor
n21:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n10:GA204%2F08%2F1530 n10:IAA500040801 n10:LC06035
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
77
n3:tvurceVysledku
Mandáková, Terezie Fajkus, Jiří Fojtová, Miloslava Majerová, Eva
n3:wos
000299051300002
n3:zamer
n14:MSM0021622415
s:issn
0167-4412
s:numberOfPages
4
n17:doi
10.1007/s11103-011-9834-5
n18:organizacniJednotka
14740