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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F13%3A00065956%21RIV14-MSM-14330___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S1571066113000212
dcterms:description
In this paper, a novel approach to discrete modeling of gene regulatory networks is presented. The approach is based on timed automata and is new in: (i) reflecting discrete abstraction of gene expression with arbitrary granularity, (ii) combining boolean logic with approximation of Hill kinetics. This is achieved by introducing delays that change dynamically with respect to current activity levels of regulating genes. The approach is implemented in UPPAAL and evaluated on benchmark models and on a biological case study. In this paper, a novel approach to discrete modeling of gene regulatory networks is presented. The approach is based on timed automata and is new in: (i) reflecting discrete abstraction of gene expression with arbitrary granularity, (ii) combining boolean logic with approximation of Hill kinetics. This is achieved by introducing delays that change dynamically with respect to current activity levels of regulating genes. The approach is implemented in UPPAAL and evaluated on benchmark models and on a biological case study.
dcterms:title
Timed Modelling of Gene Networks with Arbitrary Expression Level Discretization Timed Modelling of Gene Networks with Arbitrary Expression Level Discretization
skos:prefLabel
Timed Modelling of Gene Networks with Arbitrary Expression Level Discretization Timed Modelling of Gene Networks with Arbitrary Expression Level Discretization
skos:notation
RIV/00216224:14330/13:00065956!RIV14-MSM-14330___
n9:predkladatel
n21:orjk%3A14330
n4:aktivita
n23:S n23:P
n4:aktivity
P(GAP202/11/0312), S
n4:dodaniDat
n5:2014
n4:domaciTvurceVysledku
n16:8225400 n16:6500773
n4:druhVysledku
n19:D
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
111108
n4:idVysledku
RIV/00216224:14330/13:00065956
n4:jazykVysledku
n18:eng
n4:klicovaSlova
timed automata; gene regulatory networks; UPPAAL
n4:klicoveSlovo
n14:UPPAAL n14:timed%20automata n14:gene%20regulatory%20networks
n4:kontrolniKodProRIV
[FD057ACD7258]
n4:mistoKonaniAkce
Florencie
n4:mistoVydani
Neuveden
n4:nazevZdroje
Proceedings of the Third International Workshop on Interactions Between Computer Science and Biology (CS2Bio'12)
n4:obor
n6:IN
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
4
n4:projekt
n22:GAP202%2F11%2F0312
n4:rokUplatneniVysledku
n5:2013
n4:tvurceVysledku
Van Goethem, Simon Brim, Luboš Šafránek, David Jacquet, Jean-Marie
n4:typAkce
n12:WRD
n4:zahajeniAkce
2012-01-01+01:00
s:issn
1571-0661
s:numberOfPages
15
n8:doi
10.1016/j.entcs.2013.02.019
n13:hasPublisher
Elsevier
n17:organizacniJednotka
14330