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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F11%3A00053157%21RIV12-MSM-14330___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Apoptosis is a natural form of cell death involved in many physiological changes in the cell. During some forms of cell death, proteins endonuclease G (EndoG) and apoptosis-inducing factor (AIF) are released from mitochondria and then they translocate into the cell nuclei, where they participate in chromatin degradation in a caspase-independent way. The C. elegans homolog of AIF was shown to induce apoptosis and to interact with a homolog of EndoG and together they mediated chromatin DNA degradation. Our results show that EndoG interacts with histone H2B, AIF, and DNA topoisomerase II alpha (TOPO2a). Also AIF was found to interact with TOPO2a. Therefore we can conclude that EndoG, AIF, and TOPO2a may form a protein complex allowing chromatin degradation in apoptotic nucleus. These results offer an important insight into the mechanism of apoptotic cell death, which plays a major role in development and progression of degenerative diseases, cancer, and inflammation. Apoptosis is a natural form of cell death involved in many physiological changes in the cell. During some forms of cell death, proteins endonuclease G (EndoG) and apoptosis-inducing factor (AIF) are released from mitochondria and then they translocate into the cell nuclei, where they participate in chromatin degradation in a caspase-independent way. The C. elegans homolog of AIF was shown to induce apoptosis and to interact with a homolog of EndoG and together they mediated chromatin DNA degradation. Our results show that EndoG interacts with histone H2B, AIF, and DNA topoisomerase II alpha (TOPO2a). Also AIF was found to interact with TOPO2a. Therefore we can conclude that EndoG, AIF, and TOPO2a may form a protein complex allowing chromatin degradation in apoptotic nucleus. These results offer an important insight into the mechanism of apoptotic cell death, which plays a major role in development and progression of degenerative diseases, cancer, and inflammation.
dcterms:title
Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells
skos:prefLabel
Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells
skos:notation
RIV/00216224:14330/11:00053157!RIV12-MSM-14330___
n13:predkladatel
n14:orjk%3A14330
n3:aktivita
n4:P n4:Z
n3:aktivity
P(2B06052), P(LC535), Z(MSM0021622419)
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n7:8682968 n7:9465146 n7:3021475 n7:1723162
n3:druhVysledku
n18:O
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
197468
n3:idVysledku
RIV/00216224:14330/11:00053157
n3:jazykVysledku
n17:eng
n3:klicovaSlova
endonuclease G; histone 2B; DNA topoisomerase; apoptosis-inducing factor; microscopy of living cells; FRET.
n3:klicoveSlovo
n5:microscopy%20of%20living%20cells n5:FRET. n5:DNA%20topoisomerase n5:histone%202B n5:apoptosis-inducing%20factor n5:endonuclease%20G
n3:kontrolniKodProRIV
[AA72FE77C11F]
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n6:2B06052 n6:LC535
n3:rokUplatneniVysledku
n12:2011
n3:tvurceVysledku
Vařecha, Miroslav Matula, Pavel Kozubek, Michal Potěšilová, Michaela
n3:zamer
n15:MSM0021622419
n10:organizacniJednotka
14330