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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F11%3A00052648%21RIV12-MSM-14330___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication, we performed a siRNA screen of the human kinome and identified 13 different kinases, including phosphatidylinositol-4 kinase III alpha (PI4KIIIalfa), as being required for HCV replication. Consistent with elevated levels of the PI4KIIIalfa product phosphatidylinositol-4-phosphate (PI4P) detected in HCV-infected cultured hepatocytes and liver tissue from chronic hepatitis C patients, the enzymatic activity of PI4KIIIalfa was critical for HCV replication. Viral nonstructural protein 5A (NS5A) was found to interact with PI4KIIIalfa and stimulate its kinase activity. The absence of PI4KIIIalfa activity induced a dramatic change in the ultrastructural morphology of the membranous HCV replication complex. Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication, we performed a siRNA screen of the human kinome and identified 13 different kinases, including phosphatidylinositol-4 kinase III alpha (PI4KIIIalfa), as being required for HCV replication. Consistent with elevated levels of the PI4KIIIalfa product phosphatidylinositol-4-phosphate (PI4P) detected in HCV-infected cultured hepatocytes and liver tissue from chronic hepatitis C patients, the enzymatic activity of PI4KIIIalfa was critical for HCV replication. Viral nonstructural protein 5A (NS5A) was found to interact with PI4KIIIalfa and stimulate its kinase activity. The absence of PI4KIIIalfa activity induced a dramatic change in the ultrastructural morphology of the membranous HCV replication complex.
dcterms:title
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.
skos:prefLabel
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.
skos:notation
RIV/00216224:14330/11:00052648!RIV12-MSM-14330___
n7:predkladatel
n8:orjk%3A14330
n4:aktivita
n19:P n19:Z
n4:aktivity
P(2B06052), Z(MSM0021622419)
n4:cisloPeriodika
1
n4:dodaniDat
n15:2012
n4:domaciTvurceVysledku
n20:8544212
n4:druhVysledku
n18:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n21:predkladatel
n4:idSjednocenehoVysledku
226000
n4:idVysledku
RIV/00216224:14330/11:00052648
n4:jazykVysledku
n17:eng
n4:klicovaSlova
RNA REPLICATION; PHOSPHATIDYLINOSITOL 4-KINASES; CELLULAR COFACTORS; CORE PROTEIN; HOST FACTORS; HUH-7 CELLS; INFECTION; COMPLEX; IDENTIFICATION; SCREEN
n4:klicoveSlovo
n6:INFECTION n6:PHOSPHATIDYLINOSITOL%204-KINASES n6:CELLULAR%20COFACTORS n6:HUH-7%20CELLS n6:HOST%20FACTORS n6:SCREEN n6:IDENTIFICATION n6:RNA%20REPLICATION n6:CORE%20PROTEIN n6:COMPLEX
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[38F93BDB9FB7]
n4:nazevZdroje
Cell Host & Microbe
n4:obor
n11:EE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
24
n4:projekt
n10:2B06052
n4:rokUplatneniVysledku
n15:2011
n4:svazekPeriodika
9
n4:tvurceVysledku
Eils, Roland Bartenschlager, Ralf Lengauer, T. Ramirez, F. Matula, Petr Bühler, S. Albrecht, M. Kaul, A. Hiet, M. S. Blankenburg, H. Reiss, S. Poenisch, Marion Diehl, S. Erfle, Holger Pepperkok, Rainer Longerich, T. Romero-Brey, I. Schirmacher, P. Rebhan, Ilka Kaderali, Lars Lohmann, V. Balla, T. Backes, P. Rohr, Karl
n4:wos
000287344500006
n4:zamer
n12:MSM0021622419
s:issn
1931-3128
s:numberOfPages
14
n13:doi
10.1016/j.chom.2010.12.002
n16:organizacniJednotka
14330