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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F10%3A00051236%21RIV12-MSM-14330___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract
dcterms:description
Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency. Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency.
dcterms:title
SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement
skos:prefLabel
SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement
skos:notation
RIV/00216224:14330/10:00051236!RIV12-MSM-14330___
n3:aktivita
n13:Z n13:P
n3:aktivity
P(2B06052), P(LC06027), P(LC535), P(ME 919), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622415)
n3:cisloPeriodika
5
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n4:1723162 n4:3129888 n4:9465146 n4:1270494
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
291229
n3:idVysledku
RIV/00216224:14330/10:00051236
n3:jazykVysledku
n21:eng
n3:klicovaSlova
SUV39h; histone methyltransferases; telomeres; PML bodies; LMNA gene; epigenetics; chromatin structure; nuclear radial distributions; image analysis
n3:klicoveSlovo
n5:nuclear%20radial%20distributions n5:LMNA%20gene n5:histone%20methyltransferases n5:SUV39h n5:chromatin%20structure n5:PML%20bodies n5:telomeres n5:epigenetics n5:image%20analysis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[B1DF20C68C85]
n3:nazevZdroje
Journal of Cellular Biochemistry
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
11
n3:projekt
n7:ME%20919 n7:LC06027 n7:2B06052 n7:LC535
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
109
n3:tvurceVysledku
Vařecha, Miroslav Legartová, Soňa Amrichová, Jana Fojtová, Miloslava Galiová, Gabriela Uhlířová, Radka Matula, Pavel Bártová, Eva Harničarová, Andrea Kozubek, Stanislav Vondráček, Jan
n3:wos
000276418900010
n3:zamer
n12:AV0Z50040507 n12:AV0Z50040702 n12:MSM0021622415
s:issn
0730-2312
s:numberOfPages
12
n16:doi
10.1002/jcb.22466
n20:organizacniJednotka
14330