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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F10%3A00051235%21RIV12-MSM-14330___
rdf:type
skos:Concept n8:Vysledek
rdfs:seeAlso
http://www.springerlink.com/content/03353h53h300j70k/
dcterms:description
Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin. We observed that HP1beta is located in both the chromocenters and fibrillarin-positive nucleoli interiors. However, HP1alfa and HP1gamma occupied fibrillarin-positive compartments to a lesser extent, corresponding to the distinct levels of HP1 subtypes at the promoter of rDNA genes. Deficiency of histone methyltransferases SUV39h, and/or inhibition of histone deacetylases (HDACi) decreased HP1beta and H3K9 trimethylation at chromocenters, but not in fibrillarin-positive regions that co-localized with RNA Pol I. Similarly, SUV39h- and HDACi-dependent nucleolar rearrangement and inhibition of rDNA transcription did not affect the association between HP1beta - and fibrillarin. The presence of HP1beta in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes. Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin. We observed that HP1beta is located in both the chromocenters and fibrillarin-positive nucleoli interiors. However, HP1alfa and HP1gamma occupied fibrillarin-positive compartments to a lesser extent, corresponding to the distinct levels of HP1 subtypes at the promoter of rDNA genes. Deficiency of histone methyltransferases SUV39h, and/or inhibition of histone deacetylases (HDACi) decreased HP1beta and H3K9 trimethylation at chromocenters, but not in fibrillarin-positive regions that co-localized with RNA Pol I. Similarly, SUV39h- and HDACi-dependent nucleolar rearrangement and inhibition of rDNA transcription did not affect the association between HP1beta - and fibrillarin. The presence of HP1beta in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes.
dcterms:title
SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions
skos:prefLabel
SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions SUV39h-independent association of HP1b with fibrillarin-positive nucleolar regions
skos:notation
RIV/00216224:14330/10:00051235!RIV12-MSM-14330___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(1QS500040508), P(2B06052), P(LC535), P(ME 919), Z(AV0Z50040507), Z(AV0Z50040702)
n3:cisloPeriodika
3
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n12:9465146
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
291230
n3:idVysledku
RIV/00216224:14330/10:00051235
n3:jazykVysledku
n7:eng
n3:klicovaSlova
SUV39h; heterochromatin protein 1; nucleoli; cell nucleus
n3:klicoveSlovo
n4:heterochromatin%20protein%201 n4:SUV39h n4:nucleoli n4:cell%20nucleus
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[25642B71BD87]
n3:nazevZdroje
Chromosoma
n3:obor
n20:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n6:1QS500040508 n6:ME%20919 n6:2B06052 n6:LC535
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
119
n3:tvurceVysledku
Uhlířová, Radka Galiová, Gabriela Matula, Pavel Kozubek, Stanislav Harničarová, Andrea Bártová, Eva
n3:wos
000277786400001
n3:zamer
n14:AV0Z50040702 n14:AV0Z50040507
s:issn
0009-5915
s:numberOfPages
15
n18:doi
10.1007/s00412-009-0252-2
n21:organizacniJednotka
14330