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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F10%3A00045383%21RIV11-MSM-14330___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Lung surfactants primary function is to lower surface tension and therefore it protects alveoli from collapsing. It consists of phospholipids and four proteins. These proteins stabilize the surfactant layer (SFTPB and SFTPC) and modulate immunological response to various pathogens (SFTPA, SFTPD), which is the secondary role of lung surfactant. Low levels of surfactant proteins lead to severe diseases. Dexamethasone and insulin were applied on H441 cell line. This cell line resembles Clara cells and therefore serves as a model of lung surfactant producing cells. SFTPA1 (and its analog SFTPA2) were not affected by insulin (2500 ng/mL), but dexamethasone treatment (10-7 M) for 48 hours resulted in 50% decrease in their mRNA production. Surprisingly, combination of dexamethasone and insulin resulted in 90% decrease. Lung surfactants primary function is to lower surface tension and therefore it protects alveoli from collapsing. It consists of phospholipids and four proteins. These proteins stabilize the surfactant layer (SFTPB and SFTPC) and modulate immunological response to various pathogens (SFTPA, SFTPD), which is the secondary role of lung surfactant. Low levels of surfactant proteins lead to severe diseases. Dexamethasone and insulin were applied on H441 cell line. This cell line resembles Clara cells and therefore serves as a model of lung surfactant producing cells. SFTPA1 (and its analog SFTPA2) were not affected by insulin (2500 ng/mL), but dexamethasone treatment (10-7 M) for 48 hours resulted in 50% decrease in their mRNA production. Surprisingly, combination of dexamethasone and insulin resulted in 90% decrease.
dcterms:title
Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels
skos:prefLabel
Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels
skos:notation
RIV/00216224:14330/10:00045383!RIV11-MSM-14330___
n3:aktivita
n16:P n16:Z
n3:aktivity
P(2B06052), Z(MSM0021622430)
n3:dodaniDat
n5:2011
n3:domaciTvurceVysledku
n4:6723381 n4:8682968 n4:7454651 n4:9619658 n4:2346257 n4:4748891 n4:8836086
n3:druhVysledku
n11:D
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
254040
n3:idVysledku
RIV/00216224:14330/10:00045383
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Lung surfactant; Insulin; Dexamethasone
n3:klicoveSlovo
n15:Lung%20surfactant n15:Dexamethasone n15:Insulin
n3:kontrolniKodProRIV
[31D229F878C6]
n3:mistoKonaniAkce
Brno, Česká Republika
n3:mistoVydani
Brno, Česká republika
n3:nazevZdroje
Advances in Molecular and Cancer Biology, 2010
n3:obor
n8:EB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n18:2B06052
n3:rokUplatneniVysledku
n5:2010
n3:tvurceVysledku
Krontorád Koutná, Irena Potěšilová, Michaela Doležel, Jan Vaňhara, Petr Stejskal, Stanislav Ručka, Zdeněk Tesařová, Lenka
n3:typAkce
n7:EUR
n3:zahajeniAkce
2010-11-11+01:00
n3:zamer
n6:MSM0021622430
s:numberOfPages
3
n22:hasPublisher
muni PRESS
n21:isbn
978-80-210-5312-0
n10:organizacniJednotka
14330