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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F09%3A00029126%21RIV11-GA0-14330___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the membranes of various organelles. The highest concentration of AMID was observed associated with the Golgi. We did not observe its translocation into the nucleus during apoptosis. The proposed role of AMID in apoptosis was thus not observed. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modelling of proteins with unknown 3D structure: endonuclease G, CPS-6, WAH-1, and HSP70-1. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results present new data about the structure, localization, functions and interactions of proteins AMID, AIF, endonuclease G, and other proteins. We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the membranes of various organelles. The highest concentration of AMID was observed associated with the Golgi. We did not observe its translocation into the nucleus during apoptosis. The proposed role of AMID in apoptosis was thus not observed. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modelling of proteins with unknown 3D structure: endonuclease G, CPS-6, WAH-1, and HSP70-1. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results present new data about the structure, localization, functions and interactions of proteins AMID, AIF, endonuclease G, and other proteins.
dcterms:title
Prediction of localization and interactions of apoptotic proteins Prediction of localization and interactions of apoptotic proteins
skos:prefLabel
Prediction of localization and interactions of apoptotic proteins Prediction of localization and interactions of apoptotic proteins
skos:notation
RIV/00216224:14330/09:00029126!RIV11-GA0-14330___
n4:aktivita
n8:Z n8:P
n4:aktivity
P(2B06052), P(GP204/05/P090), P(LC535), Z(MSM0021622419)
n4:cisloPeriodika
59
n4:dodaniDat
n15:2011
n4:domaciTvurceVysledku
n7:9238174 n7:9465146 n7:1723162 n7:3021475 n7:9928758
n4:druhVysledku
n16:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
335450
n4:idVysledku
RIV/00216224:14330/09:00029126
n4:jazykVysledku
n13:eng
n4:klicovaSlova
AIF; apoptosis-inducing factor; AMID; AIF-homologous mitochondrion-associated inducer of death; endonuclease G; heat shock protein; DNA topoisomerase II; CPS-6; CED-3 protease suppressor; WAH-1
n4:klicoveSlovo
n9:AIF n9:AMID n9:WAH-1 n9:endonuclease%20G n9:CPS-6 n9:AIF-homologous%20mitochondrion-associated%20inducer%20of%20death n9:apoptosis-inducing%20factor n9:CED-3%20protease%20suppressor n9:heat%20shock%20protein n9:DNA%20topoisomerase%20II
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[6ED968DF0BB5]
n4:nazevZdroje
Journal of Biomedical Science
n4:obor
n17:EB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
6
n4:projekt
n18:2B06052 n18:GP204%2F05%2FP090 n18:LC535
n4:rokUplatneniVysledku
n15:2009
n4:svazekPeriodika
16
n4:tvurceVysledku
Vařecha, Miroslav Ulman, Vladimír Kozubek, Michal Amrichová, Jana Zimmermann, Michal Matula, Pavel
n4:wos
000268893400002
n4:zamer
n5:MSM0021622419
s:issn
1021-7770
s:numberOfPages
14
n12:organizacniJednotka
14330