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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F08%3A00024764%21RIV11-GA0-14330___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
During apoptosis several mitochondrial proteins are released. They participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF, also PDCD8 or AIFM1) and endonuclease G. Another interesting protein, which was expected to act similarly as AIF due to the high sequence homology with AIF is AIF-homologous mitochondrion-associated inducer of death (AMID, also PRG3 or AIFM2). We studied the cellular localization and colocalization of proteins AIF, endonuclease G and AMID experimentally using vectors encoding proteins of interest fused to the fluorescent proteins and using bioinformatic predictions, that analyze the amino acid sequence of the proteins with various algorithms. We confirmed the colocalization of AIF and endonuclease G in the mitochondria of human cells. AMID was found to be the cytoplasmic protein, bound to various cellular surfaces from their cytoplasmic side. During apoptosis several mitochondrial proteins are released. They participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF, also PDCD8 or AIFM1) and endonuclease G. Another interesting protein, which was expected to act similarly as AIF due to the high sequence homology with AIF is AIF-homologous mitochondrion-associated inducer of death (AMID, also PRG3 or AIFM2). We studied the cellular localization and colocalization of proteins AIF, endonuclease G and AMID experimentally using vectors encoding proteins of interest fused to the fluorescent proteins and using bioinformatic predictions, that analyze the amino acid sequence of the proteins with various algorithms. We confirmed the colocalization of AIF and endonuclease G in the mitochondria of human cells. AMID was found to be the cytoplasmic protein, bound to various cellular surfaces from their cytoplasmic side.
dcterms:title
Bioinformatic prediction, molecular modelling and image analysis of localization and interactions of apoptotic proteins endonuclease G, AIF, and AMID Bioinformatic prediction, molecular modelling and image analysis of localization and interactions of apoptotic proteins endonuclease G, AIF, and AMID
skos:prefLabel
Bioinformatic prediction, molecular modelling and image analysis of localization and interactions of apoptotic proteins endonuclease G, AIF, and AMID Bioinformatic prediction, molecular modelling and image analysis of localization and interactions of apoptotic proteins endonuclease G, AIF, and AMID
skos:notation
RIV/00216224:14330/08:00024764!RIV11-GA0-14330___
n3:aktivita
n8:P n8:Z
n3:aktivity
P(GP204/05/P090), P(LC535), Z(MSM0021622419)
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n5:9928758 n5:3021475 n5:1723162 n5:9465146 n5:9238174 n5:1270494
n3:druhVysledku
n7:O
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
358072
n3:idVysledku
RIV/00216224:14330/08:00024764
n3:jazykVysledku
n18:eng
n3:klicovaSlova
AIF; AMID; endonuclease G; image analysis; living cells; microscopy; prediction; bioinformatics
n3:klicoveSlovo
n4:microscopy n4:endonuclease%20G n4:living%20cells n4:AIF n4:AMID n4:bioinformatics n4:image%20analysis n4:prediction
n3:kontrolniKodProRIV
[F912DF0AB972]
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n6:LC535 n6:GP204%2F05%2FP090
n3:rokUplatneniVysledku
n9:2008
n3:tvurceVysledku
Ulman, Vladimír Matula, Pavel Amrichová, Jana Vařecha, Miroslav Kozubek, Michal Zimmermann, Michal
n3:zamer
n13:MSM0021622419
n11:organizacniJednotka
14330