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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F07%3A00020821%21RIV11-GA0-14330___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The main goal of this study was to compare the telomere localizations, dynamics, and occurrences of telomere associations (TAs) in healthy cells, in tumor cells with active telomerase, and in tumor cells with mechanism of alternative lengthening of telomeres (ALT). These objectives were pursued by time-lapse microscopy of living cells and by visualizing telomeres with subtelomere DNA probes in repeated double-color fluorescence in situ hybridization (FISH) on 2D fixed nuclei. Samples were observed by high-resolution cytometry, and followed by image and statistical analysis of acquired data. As models for in situ experiments were chosen following lung tissue cell lines: cell line WI-38 (healthy lung fibroblasts), tumor cell line HT-1080 with active telomerase, and cell line WI-38 VA-13/2RA (VA-13) with ALT mechanism. The main goal of this study was to compare the telomere localizations, dynamics, and occurrences of telomere associations (TAs) in healthy cells, in tumor cells with active telomerase, and in tumor cells with mechanism of alternative lengthening of telomeres (ALT). These objectives were pursued by time-lapse microscopy of living cells and by visualizing telomeres with subtelomere DNA probes in repeated double-color fluorescence in situ hybridization (FISH) on 2D fixed nuclei. Samples were observed by high-resolution cytometry, and followed by image and statistical analysis of acquired data. As models for in situ experiments were chosen following lung tissue cell lines: cell line WI-38 (healthy lung fibroblasts), tumor cell line HT-1080 with active telomerase, and cell line WI-38 VA-13/2RA (VA-13) with ALT mechanism.
dcterms:title
Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines
skos:prefLabel
Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines
skos:notation
RIV/00216224:14330/07:00020821!RIV11-GA0-14330___
n3:aktivita
n12:Z n12:P
n3:aktivity
P(GP204/05/P090), P(LC535), Z(MSM0021622419)
n3:dodaniDat
n5:2011
n3:domaciTvurceVysledku
n10:1723162 n10:4259068 n10:8202575 n10:8491313 n10:5014409 n10:3021475 n10:1270494
n3:druhVysledku
n15:O
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
451414
n3:idVysledku
RIV/00216224:14330/07:00020821
n3:jazykVysledku
n17:eng
n3:klicovaSlova
telomere; chromosome; spatial organization; telomerase; ALT mechanism
n3:klicoveSlovo
n8:telomerase n8:telomere n8:chromosome n8:spatial%20organization n8:ALT%20mechanism
n3:kontrolniKodProRIV
[2F7F607B0B37]
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n9:GP204%2F05%2FP090 n9:LC535
n3:rokUplatneniVysledku
n5:2007
n3:tvurceVysledku
Lukášová, Emilie Kozubek, Michal Vařecha, Miroslav Amrichová, Jana Kozubek, Stanislav Fajkus, Jiří Medříková, Daša
n3:zamer
n4:MSM0021622419
n13:organizacniJednotka
14330