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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F06%3A00040618%21RIV11-AV0-14330___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Recurring chromosomal abnormalities are associated with specific tumour types. The EWSR1 and FLI1 genes are involved in balanced translocation t(11;22)(q24;q12), which is present in more than 85% of Ewing sarcomas. In our previous study, we have found that the fusion genes pertaining to both derivative chromosomes 11 and 22 in Ewing sarcoma cell nuclei are shifted to the midway nuclear position between the native EWSR1 and FLI1 genes. In this contribution we focused our attention at nuclear positioning of other genetic elements of chromosomes 11 and 22 in order to find if the whole derivative chromosomes or only their translocated parts change their nuclear positions in comparison with the native chromosomes. Using repeated fluorescence in situ hybridization and high-resolution cytometry, 2D radial positions of EWSR1, BCR, FLI1, BCL1 genes and fluorescence weight centres of chromosome territories were compared for intact and derivative chromosomes 11 and 22 in nuclei of three Ewing sarcoma samples. Recurring chromosomal abnormalities are associated with specific tumour types. The EWSR1 and FLI1 genes are involved in balanced translocation t(11;22)(q24;q12), which is present in more than 85% of Ewing sarcomas. In our previous study, we have found that the fusion genes pertaining to both derivative chromosomes 11 and 22 in Ewing sarcoma cell nuclei are shifted to the midway nuclear position between the native EWSR1 and FLI1 genes. In this contribution we focused our attention at nuclear positioning of other genetic elements of chromosomes 11 and 22 in order to find if the whole derivative chromosomes or only their translocated parts change their nuclear positions in comparison with the native chromosomes. Using repeated fluorescence in situ hybridization and high-resolution cytometry, 2D radial positions of EWSR1, BCR, FLI1, BCL1 genes and fluorescence weight centres of chromosome territories were compared for intact and derivative chromosomes 11 and 22 in nuclei of three Ewing sarcoma samples.
dcterms:title
Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells
skos:prefLabel
Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells
skos:notation
RIV/00216224:14330/06:00040618!RIV11-AV0-14330___
n3:aktivita
n10:P n10:V n10:Z
n3:aktivity
P(1A8241), P(1QS500040508), P(GA202/04/0907), P(IAA5004306), P(LC535), V, Z(AV0Z50040507)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n8:8491313 n8:3021475 n8:8652589 n8:4873130 n8:1799851
n3:druhVysledku
n5:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
483514
n3:idVysledku
RIV/00216224:14330/06:00040618
n3:jazykVysledku
n13:eng
n3:klicovaSlova
HIGH-RESOLUTION CYTOMETRY; HUMAN LEUKEMIC-CELLS; HUMAN-LYMPHOCYTES; EXCHANGE ABERRATIONS; SPATIAL-ORGANIZATION; INTERPHASE NUCLEUS; BCR GENES; DOMAINS; CYCLE; TOPOGRAPHY
n3:klicoveSlovo
n12:EXCHANGE%20ABERRATIONS n12:HUMAN%20LEUKEMIC-CELLS n12:HUMAN-LYMPHOCYTES n12:BCR%20GENES n12:CYCLE n12:TOPOGRAPHY n12:DOMAINS n12:SPATIAL-ORGANIZATION n12:INTERPHASE%20NUCLEUS n12:HIGH-RESOLUTION%20CYTOMETRY
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D5D9A0A63614]
n3:nazevZdroje
Journal of Structural Biology
n3:obor
n6:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n11:GA202%2F04%2F0907 n11:LC535 n11:1A8241 n11:IAA5004306 n11:1QS500040508
n3:rokUplatneniVysledku
n9:2006
n3:svazekPeriodika
155
n3:tvurceVysledku
Bártová, Eva Taslerová, Renata Gajdušková, Pavla Kozubek, Stanislav Kozubek, Michal Kodet, Roman
n3:zamer
n17:AV0Z50040507
s:issn
1047-8477
s:numberOfPages
12
n18:organizacniJednotka
14330