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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F06%3A00019085%21RIV10-MZ0-14330___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Complexes of antigen and antibody participate in activation of the complement system. The goal of our study was to determine whether decrease in serum immunoglobulin levels in patients with hypogammaglobulinemia leads to abnormalities in complement activation. The levels of complement activation products C4d and the C5-9 complex were determined by ELISA in 30 patients with the most frequent primary hypogammaglobulinemia - common variable immunodeficiency (CVID) and in a control group of 60 (for C4d) and 40 healthy persons (for the C5-9 complex). All patients with CVID were treated by intravenous immunoglobulin in a dose of 250 - 500 mg/kg every 3 - 4 weeks. The patients had no symptoms of acute inflammatory process at the time of blood collection. The levels of the complement activation products were correlated with the serum levels of IgG (at the time of diagnosis and at the time of blood sampling) and also with the number of acute infections during the year prior to the study. Complexes of antigen and antibody participate in activation of the complement system. The goal of our study was to determine whether decrease in serum immunoglobulin levels in patients with hypogammaglobulinemia leads to abnormalities in complement activation. The levels of complement activation products C4d and the C5-9 complex were determined by ELISA in 30 patients with the most frequent primary hypogammaglobulinemia - common variable immunodeficiency (CVID) and in a control group of 60 (for C4d) and 40 healthy persons (for the C5-9 complex). All patients with CVID were treated by intravenous immunoglobulin in a dose of 250 - 500 mg/kg every 3 - 4 weeks. The patients had no symptoms of acute inflammatory process at the time of blood collection. The levels of the complement activation products were correlated with the serum levels of IgG (at the time of diagnosis and at the time of blood sampling) and also with the number of acute infections during the year prior to the study.
dcterms:title
Complement activation products in patients with common variable immunodeficiency Complement activation products in patients with common variable immunodeficiency
skos:prefLabel
Complement activation products in patients with common variable immunodeficiency Complement activation products in patients with common variable immunodeficiency
skos:notation
RIV/00216224:14330/06:00019085!RIV10-MZ0-14330___
n3:aktivita
n12:S n12:P
n3:aktivity
P(NR7921), S
n3:cisloPeriodika
4
n3:dodaniDat
n11:2010
n3:domaciTvurceVysledku
n5:7958951 n5:9731490 n5:4546628
n3:druhVysledku
n13:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
469372
n3:idVysledku
RIV/00216224:14330/06:00019085
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Hypogammaglobulinemia; Common variable immunodeficiency; Complement system; Complement activation
n3:klicoveSlovo
n4:Common%20variable%20immunodeficiency n4:Complement%20activation n4:Complement%20system n4:Hypogammaglobulinemia
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[BBC9E4CA3475]
n3:nazevZdroje
Scipta Medica (Brno)
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n9:NR7921
n3:rokUplatneniVysledku
n11:2006
n3:svazekPeriodika
79
n3:tvurceVysledku
Trávník, Jan Weignerová, Zdeňka Litzman, Jiří Bartoňková, Dana
s:issn
1211-3395
s:numberOfPages
7
n18:organizacniJednotka
14330