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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F06%3A00015475%21RIV08-AV0-14330___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Aims: Previously we identified RAGE2 haplotype in the AGER gene as a risk factor for diabetic nephropathy (DN) and single nucleotide polymorphism (SNP) 252A/G in the LTA gene as a risk factor for both DN and proliferative diabetic retinopathy (PDR). Recently, multiple SNPs in the BAT1, NFKBIL1 and LTA genes have been found associated with myocardial infarction in the genome-wide association study. Detail analysis of the given MHC III region on chromosome 6p spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci could further elucidate the character of association and help to identify causal variant. The aims of the study were (1) to construct haplotypes based on genotypes of 13 SNPs in the five genes analysed and (2) to ascertain eventual association of ceratin haplotype(s) with DN and/or PDR. Methods: A total of 981 subjects comprising four groups (DM+DN, DM+PDR, DM without complications and non-DM) were included in the study. Genotypes were detected with PCR-based methodology. Haplotypes were inferred Aims: Previously we identified RAGE2 haplotype in the AGER gene as a risk factor for diabetic nephropathy (DN) and single nucleotide polymorphism (SNP) 252A/G in the LTA gene as a risk factor for both DN and proliferative diabetic retinopathy (PDR). Recently, multiple SNPs in the BAT1, NFKBIL1 and LTA genes have been found associated with myocardial infarction in the genome-wide association study. Detail analysis of the given MHC III region on chromosome 6p spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci could further elucidate the character of association and help to identify causal variant. The aims of the study were (1) to construct haplotypes based on genotypes of 13 SNPs in the five genes analysed and (2) to ascertain eventual association of ceratin haplotype(s) with DN and/or PDR. Methods: A total of 981 subjects comprising four groups (DM+DN, DM+PDR, DM without complications and non-DM) were included in the study. Genotypes were detected with PCR-based methodology. Haplotypes were inferred Prace popisuje vysledky srovnavaci studie haplotypovych analyz u diabeticke nefropatie a retinopatie, konkretne SNPs v genech pro AGER a LTA jako varianty zodpovedne za pozorovane rozdily.
dcterms:title
Haplotype analysis of the region of 6p chromosome spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy Haplotype analysis of the region of 6p chromosome spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy Haplotypová analýza chromosomu 6p zahrnující AGER – TNFA – LTA – NFKBIL1 – BAT1 lokusy: Predběžné výsledky asociační studie u diabetické nefropatie a retinopatie
skos:prefLabel
Haplotype analysis of the region of 6p chromosome spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy Haplotype analysis of the region of 6p chromosome spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy Haplotypová analýza chromosomu 6p zahrnující AGER – TNFA – LTA – NFKBIL1 – BAT1 lokusy: Predběžné výsledky asociační studie u diabetické nefropatie a retinopatie
skos:notation
RIV/00216224:14330/06:00015475!RIV08-AV0-14330___
n3:strany
618
n3:aktivita
n6:P
n3:aktivity
P(GA310/06/0827), P(KJB501620601)
n3:cisloPeriodika
Suppl. 4
n3:dodaniDat
n4:2008
n3:domaciTvurceVysledku
n15:7988788 n15:2529947 n15:5969050 n15:9016805 n15:6918115
n3:druhVysledku
n11:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
477425
n3:idVysledku
RIV/00216224:14330/06:00015475
n3:jazykVysledku
n18:eng
n3:klicovaSlova
diabetic complications; retinopathy; haplotype
n3:klicoveSlovo
n13:retinopathy n13:haplotype n13:diabetic%20complications
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[98767B18AD86]
n3:nazevZdroje
Diabetic Medicine
n3:obor
n17:FB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n5:KJB501620601 n5:GA310%2F06%2F0827
n3:rokUplatneniVysledku
n4:2006
n3:svazekPeriodika
23
n3:tvurceVysledku
Jurajda, Michal Kolář, Petr Izakovičová-Hollá, Lydie Pácal, Lukáš Kaňková, Kateřina
s:issn
0742-3071
s:numberOfPages
1
n8:organizacniJednotka
14330