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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F06%3A00015337%21RIV10-MSM-14330___
rdf:type
skos:Concept n9:Vysledek
dcterms:description
RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels. RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels.
dcterms:title
Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
skos:prefLabel
Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
skos:notation
RIV/00216224:14330/06:00015337!RIV10-MSM-14330___
n5:aktivita
n16:P n16:Z
n5:aktivity
P(KJB501620601), Z(MSM0021620807)
n5:dodaniDat
n6:2010
n5:domaciTvurceVysledku
n11:7988788 n11:5105374 n11:8705097 n11:6108768
n5:druhVysledku
n13:O
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
497075
n5:idVysledku
RIV/00216224:14330/06:00015337
n5:jazykVysledku
n12:eng
n5:klicovaSlova
diabetic nephropathy; RAGE; polymorphism; sRAGE; renal failure
n5:klicoveSlovo
n8:polymorphism n8:renal%20failure n8:sRAGE n8:RAGE n8:diabetic%20nephropathy
n5:kontrolniKodProRIV
[0DE475485656]
n5:obor
n7:FB
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
5
n5:projekt
n10:KJB501620601
n5:rokUplatneniVysledku
n6:2006
n5:tvurceVysledku
Hertlová, Miluše Kalousová, Marta Zima, Tomáš Kaňková, Kateřina Krusová, Darja
n5:zamer
n17:MSM0021620807
n15:organizacniJednotka
14330