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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F06%3A00015299%21RIV11-GA0-14330___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
The progression of colorectal cancer involves accumulation of various genetic and epigenetic events that dramatically change gene expression. The aim of this study was to investigate a possible new approach to the diagnosis of colorectal carcinoma patients, based on their gene expression profiles. Human 19K cDNA microarrays were used to analyze the gene expression profiles of 18 colorectal carcinoma patients. Transcriptome maps (TM) were analyzed to detect chromosomal regions that could serve as potential diagnostic markers for colon cancer. A comparison of TMs showed chromosome regions with conserved changes of gene expression typical of colorectal cancer in general, and also patient-specific variable regions. We identified 195 genes with significantly altered expression in colon cancer. Functional analysis of the regulated genes distinguished three main categories: biological processes, cellular components, and molecular functions. The progression of colorectal cancer involves accumulation of various genetic and epigenetic events that dramatically change gene expression. The aim of this study was to investigate a possible new approach to the diagnosis of colorectal carcinoma patients, based on their gene expression profiles. Human 19K cDNA microarrays were used to analyze the gene expression profiles of 18 colorectal carcinoma patients. Transcriptome maps (TM) were analyzed to detect chromosomal regions that could serve as potential diagnostic markers for colon cancer. A comparison of TMs showed chromosome regions with conserved changes of gene expression typical of colorectal cancer in general, and also patient-specific variable regions. We identified 195 genes with significantly altered expression in colon cancer. Functional analysis of the regulated genes distinguished three main categories: biological processes, cellular components, and molecular functions.
dcterms:title
Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays
skos:prefLabel
Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays
skos:notation
RIV/00216224:14330/06:00015299!RIV11-GA0-14330___
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1A8241), P(GA202/04/0907), P(IAA1065203), P(IAA5004306), Z(AV0Z50040507), Z(MSM0021622419)
n3:cisloPeriodika
3
n3:dodaniDat
n13:2011
n3:domaciTvurceVysledku
n8:8491313 n8:4565606 n8:4284542 n8:4748891 n8:3021475 n8:3809404 n8:4648137 n8:1904353
n3:druhVysledku
n14:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
469203
n3:idVysledku
RIV/00216224:14330/06:00015299
n3:jazykVysledku
n18:eng
n3:klicovaSlova
colorectal carcinoma; cDNA microarrays; transcriptome map; functional clustering; expression profiles
n3:klicoveSlovo
n7:cDNA%20microarrays n7:colorectal%20carcinoma n7:expression%20profiles n7:functional%20clustering n7:transcriptome%20map
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[900ABA19703E]
n3:nazevZdroje
Clinical Genetics
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:projekt
n6:GA202%2F04%2F0907 n6:IAA1065203 n6:IAA5004306 n6:1A8241
n3:rokUplatneniVysledku
n13:2006
n3:svazekPeriodika
69
n3:tvurceVysledku
Krontorád Koutná, Irena Kozubek, Michal Krontorád, Petr Kozubek, Stanislav Brázdilová, Silvie Luisa Jansová, Eva Žaloudík, Jan Svoboda, Zbyněk
n3:zamer
n15:AV0Z50040507 n15:MSM0021622419
s:issn
0009-9163
s:numberOfPages
10
n19:organizacniJednotka
14330