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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F05%3A00012958%21RIV11-GA0-14330___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone hyperacetylation, leading to decondensation of interphase chromatin, was characterized by an increase in H3(K9) and H3(K4) dimethylation and H3(K9) acetylation. The levels of all isoforms of heterochromatin protein, HP1, were reduced after HDAC inhibition. The observed changes in the protein levels were accompanied by changes in their interphase patterns. In control cells, H3(K9) acetylation and H3(K4) dimethylation were substantially reduced to a thin layer at the nuclear periphery, whereas TSA and NaBt caused the peripheral regions to become intensely acetylated at H3(K9) and dimethylated at H3(K4). The dispersed pattern of H3(K9) dimethylation was stable even at the nuclear periphery of HDACi-treated cells. The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone hyperacetylation, leading to decondensation of interphase chromatin, was characterized by an increase in H3(K9) and H3(K4) dimethylation and H3(K9) acetylation. The levels of all isoforms of heterochromatin protein, HP1, were reduced after HDAC inhibition. The observed changes in the protein levels were accompanied by changes in their interphase patterns. In control cells, H3(K9) acetylation and H3(K4) dimethylation were substantially reduced to a thin layer at the nuclear periphery, whereas TSA and NaBt caused the peripheral regions to become intensely acetylated at H3(K9) and dimethylated at H3(K4). The dispersed pattern of H3(K9) dimethylation was stable even at the nuclear periphery of HDACi-treated cells.
dcterms:title
Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases
skos:prefLabel
Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases
skos:notation
RIV/00216224:14330/05:00012958!RIV11-GA0-14330___
n4:aktivita
n8:P n8:Z
n4:aktivity
P(1A8241), P(1QS500040508), P(GA202/04/0907), P(GP202/03/D033), P(IAA5004306), P(LC535), Z(AV0Z50040507)
n4:cisloPeriodika
21
n4:dodaniDat
n14:2011
n4:domaciTvurceVysledku
n6:4873130 n6:5881684 n6:3021475 n6:1075020 n6:8491313 n6:1587242
n4:druhVysledku
n11:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
533446
n4:idVysledku
RIV/00216224:14330/05:00012958
n4:jazykVysledku
n15:eng
n4:klicovaSlova
histone dimethylation; histone acetylation; HP1 proteins; HDAC inhibitors; nuclear periphery
n4:klicoveSlovo
n5:HP1%20proteins n5:histone%20acetylation n5:nuclear%20periphery n5:histone%20dimethylation n5:HDAC%20inhibitors
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[E5B6D6569CC1]
n4:nazevZdroje
Journal of Cell Science
n4:obor
n9:EB
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
9
n4:projekt
n7:IAA5004306 n7:1A8241 n7:1QS500040508 n7:GP202%2F03%2FD033 n7:GA202%2F04%2F0907 n7:LC535
n4:rokUplatneniVysledku
n14:2005
n4:svazekPeriodika
118
n4:tvurceVysledku
Pacherník, J. Skalníková, Magdalena Kovařík, A. Kovaříková, M. Harničarová, Andrea Bártová, Eva Kozubek, Michal Hofmanová, Jiřina Kozubek, Stanislav
n4:zamer
n16:AV0Z50040507
s:issn
0021-9533
s:numberOfPages
12
n17:organizacniJednotka
14330