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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F03%3A00009644%21RIV11-AV0-14330___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The structure of chromosome territory 17 in interphase nuclei was investigated using 3D FISH and 5 DNA probes. 3D positions of the corresponding signals were determined for approximately 30-40 nuclei of Go and stimulated lymphocytes. Individual territories were then superimposed one over another in such a way that signals of the same probe were as close together as possible. The results were compared with those obtained from randomly generated points in 3D space. Optimal positioning of chromosome territories showed for the first time non-random 3D structure of interphase chromosome. It is pointed out that new mathematical methods for the investigation of the chromosome structure in interphase nuclei are needed. The structure of chromosome territory 17 in interphase nuclei was investigated using 3D FISH and 5 DNA probes. 3D positions of the corresponding signals were determined for approximately 30-40 nuclei of Go and stimulated lymphocytes. Individual territories were then superimposed one over another in such a way that signals of the same probe were as close together as possible. The results were compared with those obtained from randomly generated points in 3D space. Optimal positioning of chromosome territories showed for the first time non-random 3D structure of interphase chromosome. It is pointed out that new mathematical methods for the investigation of the chromosome structure in interphase nuclei are needed.
dcterms:title
Detailed studies of the human genome 3D structure Detailed studies of the human genome 3D structure
skos:prefLabel
Detailed studies of the human genome 3D structure Detailed studies of the human genome 3D structure
skos:notation
RIV/00216224:14330/03:00009644!RIV11-AV0-14330___
n3:aktivita
n8:P
n3:aktivity
P(IAA1065203), P(IAA5004306), P(ME 565)
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n12:3021475 n12:8491313 n12:5014409 n12:4873130
n3:druhVysledku
n13:D
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
603245
n3:idVysledku
RIV/00216224:14330/03:00009644
n3:jazykVysledku
n11:eng
n3:klicovaSlova
human genome structure
n3:klicoveSlovo
n20:human%20genome%20structure
n3:kontrolniKodProRIV
[63937FB51663]
n3:mistoKonaniAkce
Hlohovec, Czech Republic
n3:mistoVydani
Brno
n3:nazevZdroje
Biophysics of the Genome
n3:obor
n5:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n4:IAA1065203 n4:ME%20565 n4:IAA5004306
n3:rokUplatneniVysledku
n14:2003
n3:tvurceVysledku
Kozubek, Stanislav Katsuzumi, Okumura Kozubek, Michal Lukášová, Emilie Bártová, Eva
n3:typAkce
n21:EUR
n3:zahajeniAkce
2003-01-01+01:00
s:numberOfPages
5
n17:hasPublisher
Masaryk University
n6:isbn
80-210-3226-X
n10:organizacniJednotka
14330