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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F02%3A00006554%21RIV11-AV0-14330___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
A complex study of the spatial arrangement of different genetic elements (genes, centromeres and chromosomal domains) in the cell nucleus is presented and the principles of this arrangement are discussed. We show that the radial location of genetic elements in the three-dimensional (3D) space between the center of the nucleus and the nuclear membrane is element specific and dependent on the position of the element on the chromosome. In contrast, mutual angular positioning of both homologous and heterologous genetic elements is, in the majority of cases, random. In several cases, tethering of heterologous genetic elements was observed. This close proximity of specific loci may be responsible for their mutual rearrangement and the development of cancer. Comparison of our results with transcriptome maps shows that the nuclear location of chromosomal domains with highly expressed genes is more central when compared with chromosomes with low expression. A complex study of the spatial arrangement of different genetic elements (genes, centromeres and chromosomal domains) in the cell nucleus is presented and the principles of this arrangement are discussed. We show that the radial location of genetic elements in the three-dimensional (3D) space between the center of the nucleus and the nuclear membrane is element specific and dependent on the position of the element on the chromosome. In contrast, mutual angular positioning of both homologous and heterologous genetic elements is, in the majority of cases, random. In several cases, tethering of heterologous genetic elements was observed. This close proximity of specific loci may be responsible for their mutual rearrangement and the development of cancer. Comparison of our results with transcriptome maps shows that the nuclear location of chromosomal domains with highly expressed genes is more central when compared with chromosomes with low expression.
dcterms:title
3D Structure of the human genome: Order in randomness 3D Structure of the human genome: Order in randomness
skos:prefLabel
3D Structure of the human genome: Order in randomness 3D Structure of the human genome: Order in randomness
skos:notation
RIV/00216224:14330/02:00006554!RIV11-AV0-14330___
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA202/01/0197), P(GA301/01/0186), P(IBS5004010), P(NC5955), Z(AV0Z5004920), Z(MSM 143300002)
n3:cisloPeriodika
5
n3:dodaniDat
n18:2011
n3:domaciTvurceVysledku
n9:8652589 n9:1799851 n9:4748891 n9:8491313 n9:4873130 n9:5810655 n9:5014409 n9:3021475 n9:4092163
n3:druhVysledku
n11:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
671951
n3:idVysledku
RIV/00216224:14330/02:00006554
n3:jazykVysledku
n4:eng
n3:klicovaSlova
human genome structure; interphase cell nuclei
n3:klicoveSlovo
n8:human%20genome%20structure n8:interphase%20cell%20nuclei
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[D895F60DFD3F]
n3:nazevZdroje
Chromosoma
n3:obor
n19:EB
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
9
n3:projekt
n10:IBS5004010 n10:GA301%2F01%2F0186 n10:GA202%2F01%2F0197 n10:NC5955
n3:rokUplatneniVysledku
n18:2002
n3:svazekPeriodika
111
n3:tvurceVysledku
Bártová, Eva Kozubek, Stanislav Gajdušková, Pavla Kozubek, Michal Krontorád Koutná, Irena Gaňová, Alena Lukášová, Emilie Falk, Martin Taslerová, Renata
n3:zamer
n14:AV0Z5004920 n14:MSM%20143300002
s:issn
0009-5915
s:numberOfPages
11
n7:organizacniJednotka
14330