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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F00%3A00001989%21RIV%2F2002%2FGA0%2F143302%2FN
rdf:type
n11:Vysledek skos:Concept
dcterms:description
myc gene plays an essential role in the regulation of the cell cycle and differentiation. Therefore, changes of the c-myc positioning during differentiation are of great interest. As a model system of cell differentiation, the HL-60 and U-937 human leukemic cell lines, were used in our experiments. These cells can be induced to differentiation into granulocytes that represent one of the pathways of blood cell maturation. In this study, changes of the topographic characteristics of the c-myc gene (8q24), centromeric region of chromosome 8 and chromosome 8 domain during differentiation of HL-60 and U-937 cells were detected using fluorescence in situ hybridisation (FISH). FISH techniques and fluorescence microscopy combined with image acquisition and analysis (High Resolution Cytometry) were used in order to detect the topographic features of nuclear chromatin. myc gene plays an essential role in the regulation of the cell cycle and differentiation. Therefore, changes of the c-myc positioning during differentiation are of great interest. As a model system of cell differentiation, the HL-60 and U-937 human leukemic cell lines, were used in our experiments. These cells can be induced to differentiation into granulocytes that represent one of the pathways of blood cell maturation. In this study, changes of the topographic characteristics of the c-myc gene (8q24), centromeric region of chromosome 8 and chromosome 8 domain during differentiation of HL-60 and U-937 cells were detected using fluorescence in situ hybridisation (FISH). FISH techniques and fluorescence microscopy combined with image acquisition and analysis (High Resolution Cytometry) were used in order to detect the topographic features of nuclear chromatin.
dcterms:title
Nuclear topography of the c-myc gene in human leukemic cells Nuclear topography of the c-myc gene in human leukemic cells
skos:prefLabel
Nuclear topography of the c-myc gene in human leukemic cells Nuclear topography of the c-myc gene in human leukemic cells
skos:notation
RIV/00216224:14330/00:00001989!RIV/2002/GA0/143302/N
n3:strany
1
n3:aktivita
n10:Z n10:P
n3:aktivity
P(GA202/97/0874), P(GA202/98/P253), P(NM15), P(VS97031), Z(MSM 143300002)
n3:cisloPeriodika
1
n3:dodaniDat
n16:2002
n3:domaciTvurceVysledku
n4:4748891 n4:8491313 n4:4092163 n4:8652589 n4:3021475 n4:4873130 n4:5881684 n4:5014409
n3:druhVysledku
n15:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
719724
n3:idVysledku
RIV/00216224:14330/00:00001989
n3:jazykVysledku
n17:eng
n3:klicovaSlova
c-myc topography; differentiation; FISH; HL-60; U-937
n3:klicoveSlovo
n7:FISH n7:HL-60 n7:c-myc%20topography n7:U-937 n7:differentiation
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[9A8C43E9275C]
n3:nazevZdroje
Gene
n3:obor
n19:EB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n5:NM15 n5:VS97031 n5:GA202%2F98%2FP253 n5:GA202%2F97%2F0874
n3:rokUplatneniVysledku
n16:2000
n3:svazekPeriodika
244
n3:tvurceVysledku
Kozubek, Stanislav Jirsová, Pavla Kozubek, Michal Bártová, Eva Gaňová, Alena Skalníková, Magdalena Koutná, Irena Lukášová, Emilie
n3:zamer
n13:MSM%20143300002
s:issn
0378-1119
s:numberOfPages
11
n14:organizacniJednotka
14330