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Statements

Subject Item
n2:RIV%2F00216224%3A14330%2F00%3A00001821%21RIV%2F2002%2FGA0%2F143302%2FN
rdf:type
skos:Concept n15:Vysledek
dcterms:description
abl and bcr genes play an important role in the diagnostics of chronic myelogenous leukemia (CML). The translocation of these genes results in an abnormal chromosome 22 called the Philadelphia chromosome (Ph). The chimeric bcr-abl gene is a fundamental phenomenon in the pathogenesis of CML. Malignant transformation of hematopoietic cells is also accompanied by the c-myc gene changes (translocation, amplification). Nuclear topology of the abl, bcr and c-myc genes was determined in differentiated as well as in irradiated HL-60 cells using dual-color fluorescence in situ hybridisation and image analysis by means of a high resolution cytometer. After the induction of the granulocytic differentiation of HL-60 cells with all trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO), the abl and bcr homologous genes were repositioned closer to the nuclear periphery and the average distances between homologous abl-abl and bcr-bcr genes as well as between heterologous abl-bcr genes were elongated. abl and bcr genes play an important role in the diagnostics of chronic myelogenous leukemia (CML). The translocation of these genes results in an abnormal chromosome 22 called the Philadelphia chromosome (Ph). The chimeric bcr-abl gene is a fundamental phenomenon in the pathogenesis of CML. Malignant transformation of hematopoietic cells is also accompanied by the c-myc gene changes (translocation, amplification). Nuclear topology of the abl, bcr and c-myc genes was determined in differentiated as well as in irradiated HL-60 cells using dual-color fluorescence in situ hybridisation and image analysis by means of a high resolution cytometer. After the induction of the granulocytic differentiation of HL-60 cells with all trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO), the abl and bcr homologous genes were repositioned closer to the nuclear periphery and the average distances between homologous abl-abl and bcr-bcr genes as well as between heterologous abl-bcr genes were elongated.
dcterms:title
The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells
skos:prefLabel
The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells
skos:notation
RIV/00216224:14330/00:00001821!RIV/2002/GA0/143302/N
n3:strany
233
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA202/97/0874), P(GA202/98/P253), P(NM15), Z(MSM 143300002)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2002
n3:domaciTvurceVysledku
n4:9685634 n4:8491313 n4:5881684 n4:8652589 n4:3021475 n4:4873130 n4:5014409
n3:druhVysledku
n10:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
713599
n3:idVysledku
RIV/00216224:14330/00:00001821
n3:jazykVysledku
n16:eng
n3:klicovaSlova
The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells
n3:klicoveSlovo
n17:BCR%20and%20C-MYC%20genes%20in%20human%20leukemic%20cells n17:differentiation%20and%20irradiation%20on%20the%20nuclear%20location%20of%20the%20ABL n17:The%20influence%20of%20the%20cell%20cycle
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[CD398629B17F]
n3:nazevZdroje
Leukemia Research
n3:obor
n11:BO
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n8:GA202%2F97%2F0874 n8:GA202%2F98%2FP253 n8:NM15
n3:rokUplatneniVysledku
n12:2000
n3:svazekPeriodika
24
n3:tvurceVysledku
Lukášová, Emilie Kozubek, Stanislav Jirsová, Pavla Buchníčková, Kateřina Bártová, Eva Kozubek, Michal Skalníková, Magdalena
n3:zamer
n19:MSM%20143300002
s:issn
0145-2126
s:numberOfPages
9
n18:organizacniJednotka
14330