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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F97%3A00004073%21RIV%2F2002%2FMZ0%2F143102%2FN
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Growth, morphology and viability of C6 glioma cells were significantly altered only in fast growing cultures exposed to supratherapeutic doses of BSH (sodium mercaptoborate) for 48 to 72 h. Inhibition of cell proliferation and loss of semipermeability of plasma membrane of cells exposed to toxic doses of BSH were followed by apoptotic fragmentation of DNA in a small part of population. In the remaining lethally damaged cells the process of cell-destruction appeared to be inhibited. the higher uptake of BSH by transformed glial cells suggests that the BSH content in brain tumours in situ may be controlled not only by deffects in the hematoencephalic barrier but also by tumour cellphenotype. Growth, morphology and viability of C6 glioma cells were significantly altered only in fast growing cultures exposed to supratherapeutic doses of BSH (sodium mercaptoborate) for 48 to 72 h. Inhibition of cell proliferation and loss of semipermeability of plasma membrane of cells exposed to toxic doses of BSH were followed by apoptotic fragmentation of DNA in a small part of population. In the remaining lethally damaged cells the process of cell-destruction appeared to be inhibited. the higher uptake of BSH by transformed glial cells suggests that the BSH content in brain tumours in situ may be controlled not only by deffects in the hematoencephalic barrier but also by tumour cellphenotype.
dcterms:title
Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture
skos:prefLabel
Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture
skos:notation
RIV/00216224:14310/97:00004073!RIV/2002/MZ0/143102/N
n3:aktivita
n5:P
n3:aktivity
P(NF5161)
n3:dodaniDat
n8:2002
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n11:2412594
n3:druhVysledku
n20:B
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
815863
n3:idVysledku
RIV/00216224:14310/97:00004073
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture
n3:klicoveSlovo
n7:Toxicity n7:uptake%20and%20retention%20of%20sodium%20mercaptoborate%20%28BSH%29%20in%20glial%20and%20glioma%20cells%20in%20culture
n3:kontrolniKodProRIV
[A4D309AEAEA4]
n3:mistoVydani
Nizozemsko
n3:nazevEdiceCisloSvazku
Advances in neutron capture therapy. Volume II.
n3:nazevZdroje
Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture
n3:obor
n12:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetStranKnihy
6
n3:pocetTvurcuVysledku
8
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n4:NF5161
n3:rokUplatneniVysledku
n8:1997
n3:tvurceVysledku
Bačáková, Lenka Lisá, Věra Hnatowicz, Václav Kvítek, Jan Burian, Jan Španová, Alena Drahota, Zdeněk Mareš, Vladislav
s:numberOfPages
6
n10:hasPublisher
Elsevier Science
n13:isbn
24-229-570
n16:organizacniJednotka
14310