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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00079005%21RIV15-MSM-14310___
rdf:type
n16:Vysledek skos:Concept
rdfs:seeAlso
http://link.springer.com/article/10.1007%2Fs13277-014-2019-5
dcterms:description
In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors. In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors.
dcterms:title
LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.
skos:prefLabel
LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.
skos:notation
RIV/00216224:14310/14:00079005!RIV15-MSM-14310___
n3:aktivita
n8:P
n3:aktivity
P(ED2.1.00/03.0101), P(EE2.3.20.0183)
n3:cisloPeriodika
8
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n7:9637915 n7:5658179 n7:6677398 n7:1398954 n7:7739125 n7:7524188 n7:1195271 n7:6297218
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
26715
n3:idVysledku
RIV/00216224:14310/14:00079005
n3:jazykVysledku
n20:eng
n3:klicovaSlova
osteosarcoma; all-trans retinoic acid; caffeic acid; celecoxib; osteogenic differentiation
n3:klicoveSlovo
n6:caffeic%20acid n6:osteosarcoma n6:all-trans%20retinoic%20acid n6:osteogenic%20differentiation n6:celecoxib
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E8531ED747B1]
n3:nazevZdroje
Tumor Biology
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:projekt
n5:ED2.1.00%2F03.0101 n5:EE2.3.20.0183
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
35
n3:tvurceVysledku
Veselská, Renata Štěrba, Jaroslav Zitterbart, Karel Rádsetoulal, Matěj Neradil, Jakub Chlapek, Petr Chovanová, Silvia Krzyžánková, Miroslava
n3:wos
000341883500046
s:issn
1010-4283
s:numberOfPages
11
n14:doi
10.1007/s13277-014-2019-5
n19:organizacniJednotka
14310