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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00078290%21RIV15-MSM-14310___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152070
dcterms:description
Alterations in the genome that lead to changes in DNA sequence copy number are characteristic features of solid tumors. We used CGH+SNP microarray and HPV-FISH techniques for detailed screening of copy number alterations (CNAs) in a cohort of 26 patients with cervical carcinoma (CC). This approach identified CNAs in 96.2% (25/26) of tumors. Array-CGH discovered CNAs in 73.1% (19/26) of samples, HPV-FISH experiments revealed CNAs in additional 23.1% (6/26) of samples. Common gains of genetic sequences were observed in 3q (50.0%), 1q (42.4%), 19q (23.1%), while losses were frequently found in 11q (30.8%), 4q (23.1%) and 13q (19.2%). Chromosomal regions involved in loss of heterozygosity were observed in 15.4% of samples in 8q21, 11q23, 14q21 and 18q12.2. Incidence of gain 3q was associated with HPV 16 and HPV 18 positive samples and simultaneous presence of gain 1q (P = 0.033). Alterations in the genome that lead to changes in DNA sequence copy number are characteristic features of solid tumors. We used CGH+SNP microarray and HPV-FISH techniques for detailed screening of copy number alterations (CNAs) in a cohort of 26 patients with cervical carcinoma (CC). This approach identified CNAs in 96.2% (25/26) of tumors. Array-CGH discovered CNAs in 73.1% (19/26) of samples, HPV-FISH experiments revealed CNAs in additional 23.1% (6/26) of samples. Common gains of genetic sequences were observed in 3q (50.0%), 1q (42.4%), 19q (23.1%), while losses were frequently found in 11q (30.8%), 4q (23.1%) and 13q (19.2%). Chromosomal regions involved in loss of heterozygosity were observed in 15.4% of samples in 8q21, 11q23, 14q21 and 18q12.2. Incidence of gain 3q was associated with HPV 16 and HPV 18 positive samples and simultaneous presence of gain 1q (P = 0.033).
dcterms:title
Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH
skos:prefLabel
Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH
skos:notation
RIV/00216224:14310/14:00078290!RIV15-MSM-14310___
n3:aktivita
n9:S n9:P
n3:aktivity
P(EE2.3.20.0183), P(NT11089), S
n3:cisloPeriodika
8
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n8:7780486 n8:6933300 n8:9243682 n8:1756958 n8:9577130 n8:9994947
n3:druhVysledku
n12:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
18148
n3:idVysledku
RIV/00216224:14310/14:00078290
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Cervical carcinoma; whole-genome profiling; CGH+SNP microarrays; HPV-FISH; copy number alterations
n3:klicoveSlovo
n16:Cervical%20carcinoma n16:HPV-FISH n16:CGH%2BSNP%20microarrays n16:whole-genome%20profiling n16:copy%20number%20alterations
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EAB87DB267B9]
n3:nazevZdroje
International Journal of Clinical and Experimental Pathology
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:projekt
n11:NT11089 n11:EE2.3.20.0183
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
7
n3:tvurceVysledku
Brožová, Lucie Cvanová, Michaela Vallová, Vladimíra Kuglík, Petr Kašíková, Kateřina Smetana, Jan Mouková, Lucie
n3:wos
000345120900052
s:issn
1936-2625
s:numberOfPages
12
n10:organizacniJednotka
14310