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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00077777%21RIV15-MSM-14310___
rdf:type
n18:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/elan.201400288
dcterms:description
A short, single-stranded DNA fragment d(GCGAAGC) and its analogs d(GCNNNGC) carrying different trinucleotide sequences in the center of the molecule (AAA,CCC, GGG or TTT) were investigated by spectral (CD and UV spectra) and electrochemical methods (voltammetry, polyacrylamide gel electrophoresis). Our results show that (i) the central triplet GAA or AAA dramatically stabilizes DNA hairpins, (ii) a stem-loop configuration is not supported by CCC or TTT sequences, instead, these heptamers adopt bimolecular duplex forms. Finally (iii), in the case of GGG sequence a very stable supramolecular G-quadruplex is formed. A short, single-stranded DNA fragment d(GCGAAGC) and its analogs d(GCNNNGC) carrying different trinucleotide sequences in the center of the molecule (AAA,CCC, GGG or TTT) were investigated by spectral (CD and UV spectra) and electrochemical methods (voltammetry, polyacrylamide gel electrophoresis). Our results show that (i) the central triplet GAA or AAA dramatically stabilizes DNA hairpins, (ii) a stem-loop configuration is not supported by CCC or TTT sequences, instead, these heptamers adopt bimolecular duplex forms. Finally (iii), in the case of GGG sequence a very stable supramolecular G-quadruplex is formed.
dcterms:title
Dynamic Structures of DNA Heptamers with Different Central Trinucleotide Sequences Studied by Electrochemical and Spectral Methods Dynamic Structures of DNA Heptamers with Different Central Trinucleotide Sequences Studied by Electrochemical and Spectral Methods
skos:prefLabel
Dynamic Structures of DNA Heptamers with Different Central Trinucleotide Sequences Studied by Electrochemical and Spectral Methods Dynamic Structures of DNA Heptamers with Different Central Trinucleotide Sequences Studied by Electrochemical and Spectral Methods
skos:notation
RIV/00216224:14310/14:00077777!RIV15-MSM-14310___
n3:aktivita
n19:I n19:S n19:P
n3:aktivity
I, P(GAP205/12/0466), P(LH13053), S
n3:cisloPeriodika
10
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n7:6359922 n7:6871569 n7:3790185 n7:7624352
n3:druhVysledku
n20:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
12687
n3:idVysledku
RIV/00216224:14310/14:00077777
n3:jazykVysledku
n9:eng
n3:klicovaSlova
DNA heptamers; Voltammetry; Elimination voltammetric procedure; Circular dichroism; Polyacrylamide gel electrophoresis
n3:klicoveSlovo
n12:Circular%20dichroism n12:Polyacrylamide%20gel%20electrophoresis n12:DNA%20heptamers n12:Voltammetry n12:Elimination%20voltammetric%20procedure
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[E8C70AC326C1]
n3:nazevZdroje
Electroanalysis
n3:obor
n17:CF
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n6:GAP205%2F12%2F0466 n6:LH13053
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
26
n3:tvurceVysledku
Vorlíčková, Michaela Kejnovská, Iva Trnková, Libuše Pilařová, Iveta
n3:wos
000343927400006
s:issn
1040-0397
s:numberOfPages
11
n15:doi
10.1002/elan.201400288
n11:organizacniJednotka
14310