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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00077288%21RIV15-MSM-14310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells. Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells.
dcterms:title
Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy
skos:prefLabel
Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy
skos:notation
RIV/00216224:14310/14:00077288!RIV15-MSM-14310___
n3:aktivita
n17:S n17:P
n3:aktivity
P(ED1.100/02/0123), P(ED2.1.00/03.0101), P(EE2.3.20.0183), P(NT13441), S
n3:cisloPeriodika
10
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n4:6234348 n4:6659446 n4:6834965
n3:druhVysledku
n15:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
36754
n3:idVysledku
RIV/00216224:14310/14:00077288
n3:jazykVysledku
n10:eng
n3:klicovaSlova
cancer; cellular target; coumestrol; coumestan; glycyrol; psoralidin; therapy; wedelolactone
n3:klicoveSlovo
n6:therapy n6:glycyrol n6:psoralidin n6:coumestan n6:coumestrol n6:cellular%20target n6:cancer n6:wedelolactone
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[3DBE15DF3841]
n3:nazevZdroje
Anti-Cancer Agents in Medicinal Chemistry
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n9:EE2.3.20.0183 n9:ED2.1.00%2F03.0101 n9:ED1.100%2F02%2F0123 n9:NT13441
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
14
n3:tvurceVysledku
Beneš, Petr Šmarda, Jan Nehybová, Tereza
n3:wos
000345226600006
s:issn
1871-5206
s:numberOfPages
12
n16:doi
10.2174/1871520614666140713172949
n12:organizacniJednotka
14310