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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00075817%21RIV15-MSM-14310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length. Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length. Oligodeoxynucleotides (ODNs) with repetitive cytosine (C) or guanine (G) sequences are observed in the promoter region of the oncogenes and of human telomeric DNA. Here we present electrochemical and spectral studies of short C or G homo-ODNs in solutions with different pH. Electrochemistry was represented by linear sweep or cyclic voltammetry in connection with a hanging mercury drop electrode (HMDE). As a spectral method circular dichroism was used. It was found that cytosine ODNs form stable structures, the so-called i-motifs and guanine ODN structures form tetraplex via a G-quartet. Both structures are dependent on pH and the ODN chain length.
dcterms:title
Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides
skos:prefLabel
Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides Electrochemical and Spectral Analysis of Cytosine and Guanine Homo-oligodeoxynucleotides
skos:notation
RIV/00216224:14310/14:00075817!RIV15-MSM-14310___
n3:aktivita
n5:P
n3:aktivity
P(ED1.1.00/02.0068), P(LH13053)
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n7:3790185 n7:8637881
n3:druhVysledku
n9:D
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
14090
n3:idVysledku
RIV/00216224:14310/14:00075817
n3:jazykVysledku
n15:cze
n3:klicovaSlova
Oligodeoxynucleotides (ODNs); Homo-ODN; Cytosin (C); Guanin (G); Cyclic Voltammetry (CV); Linear Sweep Voltammetry (LSV); Elimination Voltammetric procedure (EVP); Circular Dichroism (CD)
n3:klicoveSlovo
n4:Circular%20Dichroism%20%28CD%29 n4:Elimination%20Voltammetric%20procedure%20%28EVP%29 n4:Oligodeoxynucleotides%20%28ODNs%29 n4:Homo-ODN n4:Cytosin%20%28C%29 n4:Guanin%20%28G%29 n4:Cyclic%20Voltammetry%20%28CV%29 n4:Linear%20Sweep%20Voltammetry%20%28LSV%29
n3:kontrolniKodProRIV
[E71B6C1DBAB1]
n3:mistoKonaniAkce
Jetřichovice
n3:mistoVydani
Jetřichovice
n3:nazevZdroje
XXXIV. Moderní Elektrochemické Metody
n3:obor
n17:CF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n12:LH13053 n12:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n14:2014
n3:tvurceVysledku
Trnková, Libuše Gurecký, Libor
n3:typAkce
n13:EUR
n3:zahajeniAkce
2014-01-01+01:00
s:numberOfPages
4
n20:hasPublisher
Srsenová Lenka - Best servis Ústí nad Labem
n21:isbn
9788090522121
n18:organizacniJednotka
14310